About SLIT and NTRK-like protein 1
SLIT and NTRK-like protein 1 (SLITRK1) is a protein
from Homo sapiens identified by UniProt accession
Q96PX8, 696 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | SLIT and NTRK-like protein 1 |
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| UniProt accession | Q96PX8 |
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| Gene | SLITRK1 |
|---|
| Organism | Homo sapiens |
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| Length | 696 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
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| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (58)
Diseases linked to this target (Open Targets).
- trichotillomania · score 0.59
- Tourette syndrome · score 0.47
- Hair-pulling · score 0.36
- mathematical ability · score 0.23
- adolescent idiopathic scoliosis · score 0.13
- obsessive-compulsive disorder · score 0.05
- Kennedy disease · score 0.04
- Testicular regression syndrome · score 0.04
- 46,XX ovotesticular disorder of sex development · score 0.04
- 46,XY complete gonadal dysgenesis · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96PX8-F1 | alphafold | PREDICTED | 76.51 | — |
Amino-acid sequence (696 residues)
MLLWILLLET SLCFAAGNVT GDVCKEKICS CNEIEGDLHV DCEKKGFTSL QRFTAPTSQF YHLFLHGNSL TRLFPNEFAN FYNAVSLHME NNGLHEIVPG AFLGLQLVKR LHINNNKIKS FRKQTFLGLD DLEYLQADFN LLRDIDPGAF QDLNKLEVLI LNDNLISTLP ANVFQYVPIT HLDLRGNRLK TLPYEEVLEQ IPGIAEILLE DNPWDCTCDL LSLKEWLENI PKNALIGRVV CEAPTRLQGK DLNETTEQDL CPLKNRVDSS LPAPPAQEET FAPGPLPTPF KTNGQEDHAT PGSAPNGGTK IPGNWQIKIR PTAAIATGSS RNKPLANSLP CPGGCSCDHI PGSGLKMNCN NRNVSSLADL KPKLSNVQEL FLRDNKIHSI RKSHFVDYKN LILLDLGNNN IATVENNTFK NLLDLRWLYM DSNYLDTLSR EKFAGLQNLE YLNVEYNAIQ LILPGTFNAM PKLRILILNN NLLRSLPVDV FAGVSLSKLS LHNNYFMYLP VAGVLDQLTS IIQIDLHGNP WECSCTIVPF KQWAERLGSE VLMSDLKCET PVNFFRKDFM LLSNDEICPQ LYARISPTLT SHSKNSTGLA ETGTHSNSYL DTSRVSISVL VPGLLLVFVT SAFTVVGMLV FILRNRKRSK RRDANSSASE INSLQTVCDS SYWHNGPYNA DGAHRVYDCG SHSLSD
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