About Pleckstrin homology domain-containing family G member 4B
Pleckstrin homology domain-containing family G member 4B (PLEKHG4B) is a protein
from Homo sapiens identified by UniProt accession
Q96PX9, 1627 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | Pleckstrin homology domain-containing family G member 4B |
|---|
| UniProt accession | Q96PX9 |
|---|
| Gene | PLEKHG4B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 1627 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (19)
Diseases linked to this target (Open Targets).
- DNA methylation · score 0.21
- Neurodevelopmental disorder · score 0.12
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- central nervous system cancer · score 0.03
- Tetralogy of Fallot · score 0.03
- gastric carcinoma · score 0.02
- metopic craniosynostosis · score 0.01
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96PX9-F1 | alphafold | PREDICTED | 58.26 | — |
Amino-acid sequence (1627 residues)
MGFSTADGGG GPGARDLESL DACIQRTLSA LYPPFEATAA TVLWQLFSVA ERCHGGDGLH CLTSFLLPAK RALQHLQQEA CARYRGLVFL HPGWPLCAHE KVVVQLASLH GVRLQPGDFY LQVTSAGKQS ARLVLKCLSR LGRGTEEVTV PEAMYGCVFT GAFLEWVNRE RRHVPLQTCL LTSGLAVHRA PWSDVTDPVF VPSPGAILQS YSSCTGPERL PSSPSEAPVP TQATAGPHFQ GSASCPDTLT SPCRRGHTGS DQLRHLPYPE RAELGSPRTL SGSSDRDFEK VSPSEQGPRM PPENCGGSGE RPDPMDQEDR PKALTFHTDL GIPSSRRRPP GDPTCVQPRR WFRESYMEAL RNPMPLGSSE EALGDLACSS LTGASRDLGT GAVASGTQEE TSGPRGDPQQ TPSLEKERHT PSRTGPGAAG RTLPRRSRSW ERAPRSSRGA QAAACHTSHH SAGSRPGGHL GGQAVGTPNC VPVEGPGCTK EEDVLASSAC VSTDGGSLHC HNPSGPSDVP ARQPHPEQEG WPPGTGDFPS QVPKQVLDVS QELLQSGVVT LPGTRDRHGR AVVQVRTRSL LWTREHSSCA ELTRLLLYFH SIPRKEVRDL GLVVLVDARR SPAAPAVSQA LSGLQNNTSP IIHSILLLVD KESAFRPDKD AIIQCEVVSS LKAVHKFVDS CQLTADLDGS FPYSHGDWIC FRQRLEHFAA NCEEAIIFLQ NSFCSLNTHR TPRTAQEVAE LIDQHETMMK LVLEDPLLVS LRLEGGTVLA RLRREELGTE DSRDTLEAAT SLYDRVDEEV HRLVLTSNNR LQQLEHLREL ASLLEGNDQQ SCQKGLQLAK ENPQRTEEMV QDFRRGLSAV VSQAECREGE LARWTRSSEL CETVSSWMGP LDPEACPSSP VAECLRSCHQ EATSVAAEAF PGAGVAVLKP HALGKPWASQ QDLWLQYPQT RLRLEEALSE AAPDPSLPPL AQSPPKHERA QEAMRRHQKP PSFPSTDSGG GAWEPAQPLS GLPGRALLCG QDGETLRPGL CALWDPLSLL RGLPGAGATT AHLEDSSACS SEPTQTLASR PRKHPQKKMI KKTQSFEIPQ PDSGPRDSCQ PDHTSVFSKG LEVTSTVATE KKLPLWQHAR SPPVTQSRSL SSPSGLHPAE EDGRQQVGSS RLRHIMAEMI ATEREYIRCL GYVIDNYFPE MERMDLPQGL RGKHHVIFGN LEKLHDFHQQ HFLRELERCQ HCPLAVGRSF LRHEEQFGMY VIYSKNKPQS DALLSSHGNA FFKDKQRELG DKMDLASYLL RPVQRVAKYA LLLQDLLKEA SCGLAQGQEL GELRAAEVVV CFQLRHGNDL LAMDAIRGCD VNLKEQGQLR CRDEFIVCCG RKKYLRHVFL FEDLILFSKT QKVEGSHDVY LYKQSFKTAE IGMTENVGDS GLRFEIWFRR RRKSQDTYIL QASSAEVKSA WTDVIGRILW RQALKSRELR IQEMASMGIG NQPFMDVKPR DRTPDCAVIS DRAPKCAVMS DRVPDSIVKG TESQMRGSTA VSSSDHAAPF KRPHSTISDS STSSSSSQSS SILGSLGLLV SSSPAHPGLW SPAHSPWSSD IRACVEEDEP EPELETGTQA AVCEGAPAVL LSRTRQA
Explore Pleckstrin homology domain-containing family G member 4B with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets