About Pseudouridylate synthase 7 homolog
Pseudouridylate synthase 7 homolog (PUS7) is a protein
from Homo sapiens identified by UniProt accession
Q96PZ0, 661 residues long.
MolForge cross-references it against 0 known binders and
68 disease associations.
Target properties
| Protein name | Pseudouridylate synthase 7 homolog |
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| UniProt accession | Q96PZ0 |
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| Gene | PUS7 |
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| Organism | Homo sapiens |
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| Length | 661 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (68)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder with abnormal behavior, microcephaly, and short stature · score 0.69
- genetic disorder · score 0.45
- Intellectual disability · score 0.37
- Microcephaly · score 0.37
- microcephaly · score 0.37
- Atypical behavior · score 0.37
- Short stature · score 0.37
- complex neurodevelopmental disorder · score 0.37
- pervasive developmental disorder · score 0.34
- Rare pervasive developmental disorder · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96PZ0-F1 | alphafold | PREDICTED | 80.13 | — |
Amino-acid sequence (661 residues)
MEMTEMTGVS LKRGALVVED NDSGVPVEET KKQKLSECSL TKGQDGLQND FLSISEDVPR PPDTVSTGKG GKNSEAQLED EEEEEEDGLS EECEEEESES FADMMKHGLT EADVGITKFV SSHQGFSGIL KERYSDFVVH EIGKDGRISH LNDLSIPVDE EDPSEDIFTV LTAEEKQRLE ELQLFKNKET SVAIEVIEDT KEKRTIIHQA IKSLFPGLET KTEDREGKKY IVAYHAAGKK ALANPRKHSW PKSRGSYCHF VLYKENKDTM DAINVLSKYL RVKPNIFSYM GTKDKRAITV QEIAVLKITA QRLAHLNKCL MNFKLGNFSY QKNPLKLGEL QGNHFTVVLR NITGTDDQVQ QAMNSLKEIG FINYYGMQRF GTTAVPTYQV GRAILQNSWT EVMDLILKPR SGAEKGYLVK CREEWAKTKD PTAALRKLPV KRCVEGQLLR GLSKYGMKNI VSAFGIIPRN NRLMYIHSYQ SYVWNNMVSK RIEDYGLKPV PGDLVLKGAT ATYIEEDDVN NYSIHDVVMP LPGFDVIYPK HKIQEAYREM LTADNLDIDN MRHKIRDYSL SGAYRKIIIR PQNVSWEVVA YDDPKIPLFN TDVDNLEGKT PPVFASEGKY RALKMDFSLP PSTYATMAIR EVLKMDTSIK NQTQLNTTWL R
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