About Derlin-3
Derlin-3 (DERL3) is a protein
from Homo sapiens identified by UniProt accession
Q96Q80, 235 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Derlin-3 |
|---|
| UniProt accession | Q96Q80 |
|---|
| Gene | DERL3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 235 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (71)
Diseases linked to this target (Open Targets).
- cystic fibrosis · score 0.46
- serum IgG glycosylation measurement · score 0.33
- total blood protein measurement · score 0.25
- serum non-albumin protein measurement · score 0.24
- hypertrophic cardiomyopathy · score 0.20
- electrocardiography · score 0.20
- PR interval · score 0.19
- IgG monogalactosylation measurement · score 0.19
- IgG bisecting N-acetyl glucosamine measurement · score 0.19
- IgG fucosylation measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96Q80-F1 | alphafold | PREDICTED | 84.21 | — |
Amino-acid sequence (235 residues)
MAWQGLAAEF LQVPAVTRAY TAACVLTTAA VQLELLSPFQ LYFNPHLVFR KFQVWRLVTN FLFFGPLGFS FFFNMLFVFR YCRMLEEGSF RGRTADFVFM FLFGGVLMTL LGLLGSLFFL GQALMAMLVY VWSRRSPRVR VNFFGLLTFQ APFLPWALMG FSLLLGNSIL VDLLGIAVGH IYYFLEDVFP NQPGGKRLLQ TPGFLKLLLD APAEDPNYLP LPEEQPGPHL PPPQQ
Explore Derlin-3 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets