About Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (ALKBH3) is a protein
from Homo sapiens identified by UniProt accession
Q96Q83, 286 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 |
|---|
| UniProt accession | Q96Q83 |
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| Gene | ALKBH3 |
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| Organism | Homo sapiens |
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| Length | 286 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (94)
Diseases linked to this target (Open Targets).
- chronotype measurement · score 0.39
- body mass index · score 0.37
- urate measurement · score 0.30
- bone density · score 0.30
- depressive disorder · score 0.27
- hair colour measurement · score 0.26
- body height · score 0.26
- breast adenocarcinoma · score 0.18
- body weight · score 0.09
- attention deficit hyperactivity disorder · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96Q83-F1 | alphafold | PREDICTED | 82.03 | — |
Amino-acid sequence (286 residues)
MEEKRRRARV QGAWAAPVKS QAIAQPATTA KSHLHQKPGQ TWKNKEHHLS DREFVFKEPQ QVVRRAPEPR VIDREGVYEI SLSPTGVSRV CLYPGFVDVK EADWILEQLC QDVPWKQRTG IREDITYQQP RLTAWYGELP YTYSRITMEP NPHWHPVLRT LKNRIEENTG HTFNSLLCNL YRNEKDSVDW HSDDEPSLGR CPIIASLSFG ATRTFEMRKK PPPEENGDYT YVERVKIPLD HGTLLIMEGA TQADWQHRVP KEYHSREPRV NLTFRTVYPD PRGAPW
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