Rab-3A-interacting protein (RAB3IP)

About Rab-3A-interacting protein

Rab-3A-interacting protein (RAB3IP) is a protein from Homo sapiens identified by UniProt accession Q96QF0, 476 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	Rab-3A-interacting protein
UniProt accession	Q96QF0
Gene	RAB3IP
Organism	Homo sapiens
Length	476 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (38)

Diseases linked to this target (Open Targets).

body height · score 0.21
gonorrhea · score 0.07
forced expiratory volume · score 0.06
hemoglobin D disease · score 0.04
FEV/FVC ratio · score 0.04
hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome · score 0.04
Adult-onset autosomal recessive sideroblastic anemia · score 0.04
atrial fibrillation · score 0.04
hemoglobin E-beta-thalassemia syndrome · score 0.03
hemoglobin E disease · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96QF0-F1	alphafold	PREDICTED	70.75	—

Amino-acid sequence (476 residues)

MGLKKMKGLS YDEAFAMAND PLEGFHEVNL ASPTSPDLLG VYESGTQEQT TSPSVIYRPH PSALSSVPIQ ANALDVSELP TQPVYSSPRR LNCAEISSIS FHVTDPAPCS TSGVTAGLTK LTTRKDNYNA EREFLQGATI TEACDGSDDI FGLSTDSLSR LRSPSVLEVR EKGYERLKEE LAKAQRELKL KDEECERLSK VRDQLGQELE ELTASLFEEA HKMVREANIK QATAEKQLKE AQGKIDVLQA EVAALKTLVL SSSPTSPTQE PLPGGKTPFK KGHTRNKSTS SAMSGSHQDL SVIQPIVKDC KEADLSLYNE FRLWKDEPTM DRTCPFLDKI YQEDIFPCLT FSKSELASAV LEAVENNTLS IEPVGLQPIR FVKASAVECG GPKKCALTGQ SKSCKHRIKL GDSSNYYYIS PFCRYRITSV CNFFTYIRYI QQGLVKQQDV DQMFWEVMQL RKEMSLAKLG YFKEEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards