About PML-RARA-regulated adapter molecule 1
PML-RARA-regulated adapter molecule 1 (PRAM1) is a protein
from Homo sapiens identified by UniProt accession
Q96QH2, 670 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | PML-RARA-regulated adapter molecule 1 |
|---|
| UniProt accession | Q96QH2 |
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| Gene | PRAM1 |
|---|
| Organism | Homo sapiens |
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| Length | 670 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (40)
Diseases linked to this target (Open Targets).
- basophil count · score 0.33
- basophil percentage of leukocytes · score 0.23
- eosinophil percentage of leukocytes · score 0.14
- fat body mass · score 0.11
- heel bone mineral density · score 0.11
- eosinophil count · score 0.09
- neutrophil immunodeficiency syndrome · score 0.07
- appendicular lean mass · score 0.05
- lean body mass · score 0.05
- acute myeloid leukemia · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96QH2-F1 | alphafold | PREDICTED | 53.99 | — |
Amino-acid sequence (670 residues)
MAHHLPAAME SHQDFRSIKA KFQASQPEPS DLPKKPPKPE FGKLKKFSQP ELSEHPKKAP LPEFGAVSLK PPPPEVTDLP KKPPPPEVTD LPKKPPPPEV TDLPKKPPPP EVTDLPKKPS KLELSDLSKK FPQLGATPFP RKPLQPEVGE APLKASLPEP GAPARKPLQP DELSHPARPP SEPKSGAFPR KLWQPEAGEA TPRSPQPELS TFPKKPAQPE FNVYPKKPPQ PQVGGLPKKS VPQPEFSEAA QTPLWKPQSS EPKRDSSAFP KKASQPPLSD FPKKPPQPEL GDLTRTSSEP EVSVLPKRPR PAEFKALSKK PPQPELGGLP RTSSEPEFNS LPRKLLQPER RGPPRKFSQP EPSAVLKRHP QPEFFGDLPR KPPLPSSASE SSLPAAVAGF SSRHPLSPGF GAAGTPRWRS GGLVHSGGAR PGLRPSHPPR RRPLPPASSL GHPPAKPPLP PGPVDMQSFR RPSAASIDLR RTRSAAGLHF QDRQPEDIPQ VPDEIYELYD DVEPRDDSSP SPKGRDEAPS VQQAARRPPQ DPALRKEKDP QPQQLPPMDP KLLKQLRKAE KAEREFRKKF KFEGEIVVHT KMMIDPNAKT RRGGGKHLGI RRGEILEVIE FTSNEEMLCR DPKGKYGYVP RTALLPLETE VYDDVDFCDP LENQPLPLGR
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