About Sorting nexin-18
Sorting nexin-18 (SNX18) is a protein
from Homo sapiens identified by UniProt accession
Q96RF0, 628 residues long.
MolForge cross-references it against 0 known binders and
35 disease associations.
Target properties
| Protein name | Sorting nexin-18 |
|---|
| UniProt accession | Q96RF0 |
|---|
| Gene | SNX18 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 628 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (35)
Diseases linked to this target (Open Targets).
- protein measurement · score 0.24
- attention deficit hyperactivity disorder · score 0.09
- attention deficit-hyperactivity disorder 8 · score 0.07
- schizophrenia 15 · score 0.07
- Tourette syndrome · score 0.06
- Phelan-McDermid syndrome · score 0.05
- autism · score 0.05
- X-linked non-syndromic intellectual disability · score 0.04
- Potocki-Lupski syndrome · score 0.04
- Red cell distribution width · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96RF0-F1 | alphafold | PREDICTED | 66.93 | — |
Amino-acid sequence (628 residues)
MALRARALYD FRSENPGEIS LREHEVLSLC SEQDIEGWLE GVNSRGDRGL FPASYVQVIR APEPGPAGDG GPGAPARYAN VPPGGFEPLP VAPPASFKPP PDAFQALLQP QQAPPPSTFQ PPGAGFPYGG GALQPSPQQL YGGYQASQGS DDDWDDEWDD SSTVADEPGA LGSGAYPDLD GSSSAGVGAA GRYRLSTRSD LSLGSRGGSV PPQHHPSGPK SSATVSRNLN RFSTFVKSGG EAFVLGEASG FVKDGDKLCV VLGPYGPEWQ ENPYPFQCTI DDPTKQTKFK GMKSYISYKL VPTHTQVPVH RRYKHFDWLY ARLAEKFPVI SVPHLPEKQA TGRFEEDFIS KRRKGLIWWM NHMASHPVLA QCDVFQHFLT CPSSTDEKAW KQGKRKAEKD EMVGANFFLT LSTPPAAALD LQEVESKIDG FKCFTKKMDD SALQLNHTAN EFARKQVTGF KKEYQKVGQS FRGLSQAFEL DQQAFSVGLN QAIAFTGDAY DAIGELFAEQ PRQDLDPVMD LLALYQGHLA NFPDIIHVQK GKAWPLEQVI WSVLCRLKGA TLTAVPLWVS ESYSTGEEAS RDVDAWVFSL ECKLDCSTGS FLLEYLALGN EYSFSKVQRV PLMTVLSF
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