BBSome complex member BBS4 (BBS4)

About BBSome complex member BBS4

BBSome complex member BBS4 (BBS4) is a protein from Homo sapiens identified by UniProt accession Q96RK4, 519 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.

Target properties

Protein name	BBSome complex member BBS4
UniProt accession	Q96RK4
Gene	BBS4
Organism	Homo sapiens
Length	519 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (115)

Diseases linked to this target (Open Targets).

Bardet-Biedl syndrome 4 · score 0.82
Bardet-Biedl syndrome · score 0.67
Bardet-Biedl syndrome 1 · score 0.49
retinitis pigmentosa · score 0.47
Polydactyly · score 0.46
polydactyly · score 0.46
body mass index · score 0.45
ciliopathy · score 0.37
Obesity · score 0.37
obesity · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96RK4-F1	alphafold	PREDICTED	77.69	—

Amino-acid sequence (519 residues)

MAEERVATRT QFPVSTESQK PRQKKAPEFP ILEKQNWLIH LHYIRKDYEA CKAVIKEQLQ ETQGLCEYAI YVQALIFRLE GNIQESLELF QTCAVLSPQS ADNLKQVARS LFLLGKHKAA IEVYNEAAKL NQKDWEISHN LGVCYIYLKQ FNKAQDQLHN ALNLNRHDLT YIMLGKIHLL EGDLDKAIEV YKKAVEFSPE NTELLTTLGL LYLQLGIYQK AFEHLGNALT YDPTNYKAIL AAGSMMQTHG DFDVALTKYR VVACAVPESP PLWNNIGMCF FGKKKYVAAI SCLKRANYLA PFDWKILYNL GLVHLTMQQY ASAFHFLSAA INFQPKMGEL YMLLAVALTN LEDIENAKRA YAEAVHLDKC NPLVNLNYAV LLYNQGEKKN ALAQYQEMEK KVSLLKDNSS LEFDSEMVEM AQKLGAALQV GEALVWTKPV KDPKSKHQTT STSKPASFQQ PLGSNQALGQ AMSSAAAYRT LPSGAGGTSQ FTKPPSLPLE PEPAVESSPT ETSEQIREK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards