About Sialic acid-binding Ig-like lectin 11
Sialic acid-binding Ig-like lectin 11 (SIGLEC11) is a protein
from Homo sapiens identified by UniProt accession
Q96RL6, 698 residues long.
MolForge cross-references it against 0 known binders and
114 disease associations.
Target properties
| Protein name | Sialic acid-binding Ig-like lectin 11 |
|---|
| UniProt accession | Q96RL6 |
|---|
| Gene | SIGLEC11 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 698 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (114)
Diseases linked to this target (Open Targets).
- platelet count · score 0.25
- common variable immunodeficiency · score 0.08
- combined immunodeficiency with skin granulomas · score 0.08
- BENTA disease · score 0.08
- Hodgkins lymphoma · score 0.07
- classic Hodgkin lymphoma · score 0.07
- Waldenstrom macroglobulinemia · score 0.07
- immunodeficiency 18 · score 0.07
- isolated agammaglobulinemia · score 0.07
- immunodeficiency 62 · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96RL6-F1 | alphafold | PREDICTED | 74.13 | — |
Amino-acid sequence (698 residues)
MVPGQAQPQS PEMLLLPLLL PVLGAGSLNK DPSYSLQVQR QVPVPEGLCV IVSCNLSYPR DGWDESTAAY GYWFKGRTSP KTGAPVATNN QSREVEMSTR DRFQLTGDPG KGSCSLVIRD AQREDEAWYF FRVERGSRVR HSFLSNAFFL KVTALTKKPD VYIPETLEPG QPVTVICVFN WAFKKCPAPS FSWTGAALSP RRTRPSTSHF SVLSFTPSPQ DHDTDLTCHV DFSRKGVSAQ RTVRLRVAYA PKDLIISISH DNTSALELQG NVIYLEVQKG QFLRLLCAAD SQPPATLSWV LQDRVLSSSH PWGPRTLGLE LRGVRAGDSG RYTCRAENRL GSQQQALDLS VQYPPENLRV MVSQANRTVL ENLGNGTSLP VLEGQSLRLV CVTHSSPPAR LSWTRWGQTV GPSQPSDPGV LELPPIQMEH EGEFTCHAQH PLGSQHVSLS LSVHYPPQLL GPSCSWEAEG LHCSCSSQAS PAPSLRWWLG EELLEGNSSQ GSFEVTPSSA GPWANSSLSL HGGLSSGLRL RCKAWNVHGA QSGSVFQLLP GKLEHGGGLG LGAALGAGVA ALLAFCSCLV VFRVKICRKE ARKRAAAEQD VPSTLGPISQ GHQHECSAGS SQDHPPPGAA TYTPGKGEEQ ELHYASLSFQ GLRLWEPADQ EAPSTTEYSE IKIHTGQPLR GPGFGLQLER EMSGMVPK
Explore Sialic acid-binding Ig-like lectin 11 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets