Urocortin-2 (UCN2)

About Urocortin-2

Urocortin-2 (UCN2) is a protein from Homo sapiens identified by UniProt accession Q96RP3, 112 residues long. MolForge cross-references it against 0 known binders and 237 disease associations.

Target properties

Protein name	Urocortin-2
UniProt accession	Q96RP3
Gene	UCN2
Organism	Homo sapiens
Length	112 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (237)

Diseases linked to this target (Open Targets).

breast ductal adenocarcinoma · score 0.11
reticulocyte count · score 0.10
low grade glioma · score 0.10
Pallister-Hall syndrome · score 0.08
systemic scleroderma · score 0.08
alkaline phosphatase measurement · score 0.06
platelet count · score 0.06
bilirubin measurement · score 0.06
Crohn's disease · score 0.05
non-small cell lung carcinoma · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96RP3-F1	alphafold	PREDICTED	69.36	—

Amino-acid sequence (112 residues)

MTRCALLLLM VLMLGRVLVV PVTPIPTFQL RPQNSPQTTP RPAASESPSA APTWPWAAQS HCSPTRHPGS RIVLSLDVPI GLLQILLEQA RARAAREQAT TNARILARVG HC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards