About Potassium voltage-gated channel subfamily A member 7
Potassium voltage-gated channel subfamily A member 7 (KCNA7) is a protein
from Homo sapiens identified by UniProt accession
Q96RP8, 456 residues long.
MolForge cross-references it against 0 known binders and
146 disease associations.
Target properties
| Protein name | Potassium voltage-gated channel subfamily A member 7 |
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| UniProt accession | Q96RP8 |
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| Gene | KCNA7 |
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| Organism | Homo sapiens |
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| Length | 456 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (146)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- small cell carcinoma · score 0.46
- Muscle weakness · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- transverse myelitis · score 0.37
- anterior ischemic optic neuropathy · score 0.37
- primary progressive multiple sclerosis · score 0.37
- atrial fibrillation · score 0.37
- atrial flutter · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96RP8-F1 | alphafold | PREDICTED | 81.09 | — |
Amino-acid sequence (456 residues)
MEPRCPPPCG CCERLVLNVA GLRFETRART LGRFPDTLLG DPARRGRFYD DARREYFFDR HRPSFDAVLY YYQSGGRLRR PAHVPLDVFL EEVAFYGLGA AALARLREDE GCPVPPERPL PRRAFARQLW LLFEFPESSQ AARVLAVVSV LVILVSIVVF CLETLPDFRD DRDGTGLAAA AAAGPFPAPL NGSSQMPGNP PRLPFNDPFF VVETLCICWF SFELLVRLLV CPSKAIFFKN VMNLIDFVAI LPYFVALGTE LARQRGVGQQ AMSLAILRVI RLVRVFRIFK LSRHSKGLQI LGQTLRASMR ELGLLIFFLF IGVVLFSSAV YFAEVDRVDS HFTSIPESFW WAVVTMTTVG YGDMAPVTVG GKIVGSLCAI AGVLTISLPV PVIVSNFSYF YHRETEGEEA GMFSHVDMQP CGPLEGKANG GLVDGEVPEL PPPLWAPPGK HLVTEV
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