About Elongation factor G, mitochondrial
Elongation factor G, mitochondrial (GFM1) is a protein
from Homo sapiens identified by UniProt accession
Q96RP9, 751 residues long.
MolForge cross-references it against 0 known binders and
103 disease associations.
Target properties
| Protein name | Elongation factor G, mitochondrial |
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| UniProt accession | Q96RP9 |
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| Gene | GFM1 |
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| Organism | Homo sapiens |
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| Length | 751 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (103)
Diseases linked to this target (Open Targets).
- Hepatoencephalopathy due to combined oxidative phosphorylation deficiency type 1 · score 0.81
- hepatoencephalopathy due to combined oxidative phosphorylation defect type 1 · score 0.77
- neurodegenerative disease · score 0.46
- combined oxidative phosphorylation deficiency · score 0.34
- diastolic blood pressure · score 0.28
- systolic blood pressure · score 0.26
- PR interval · score 0.24
- blood protein measurement · score 0.24
- genetic disorder · score 0.19
- Leigh syndrome · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96RP9-F1 | alphafold | PREDICTED | 82.07 | — |
Amino-acid sequence (751 residues)
MRLLGAAAVA ALGRGRAPAS LGWQRKQVNW KACRWSSSGV IPNEKIRNIG ISAHIDSGKT TLTERVLYYT GRIAKMHEVK GKDGVGAVMD SMELERQRGI TIQSAATYTM WKDVNINIID TPGHVDFTIE VERALRVLDG AVLVLCAVGG VQCQTMTVNR QMKRYNVPFL TFINKLDRMG SNPARALQQM RSKLNHNAAF MQIPMGLEGN FKGIVDLIEE RAIYFDGDFG QIVRYGEIPA ELRAAATDHR QELIECVANS DEQLGEMFLE EKIPSISDLK LAIRRATLKR SFTPVFLGSA LKNKGVQPLL DAVLEYLPNP SEVQNYAILN KEDDSKEKTK ILMNSSRDNS HPFVGLAFKL EVGRFGQLTY VRSYQGELKK GDTIYNTRTR KKVRLQRLAR MHADMMEDVE EVYAGDICAL FGIDCASGDT FTDKANSGLS MESIHVPDPV ISIAMKPSNK NDLEKFSKGI GRFTREDPTF KVYFDTENKE TVISGMGELH LEIYAQRLER EYGCPCITGK PKVAFRETIT APVPFDFTHK KQSGGAGQYG KVIGVLEPLD PEDYTKLEFS DETFGSNIPK QFVPAVEKGF LDACEKGPLS GHKLSGLRFV LQDGAHHMVD SNEISFIRAG EGALKQALAN ATLCILEPIM AVEVVAPNEF QGQVIAGINR RHGVITGQDG VEDYFTLYAD VPLNDMFGYS TELRSCTEGK GEYTMEYSRY QPCLPSTQED VINKYLEATG QLPVKKGKAK N
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