About Calcium/calmodulin-dependent protein kinase kinase 2
Calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) is a protein
from Homo sapiens identified by UniProt accession
Q96RR4, 588 residues long.
MolForge cross-references it against 0 known binders and
166 disease associations.
Target properties
| Protein name | Calcium/calmodulin-dependent protein kinase kinase 2 |
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| UniProt accession | Q96RR4 |
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| Gene | CAMKK2 |
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| Organism | Homo sapiens |
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| Length | 588 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (16)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (166)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.17
- body mass index · score 0.15
- neoplasm · score 0.11
- cancer · score 0.09
- breast cancer · score 0.08
- Stroke · score 0.08
- intrahepatic cholangiocarcinoma · score 0.07
- glioblastoma multiforme · score 0.06
- diastolic blood pressure · score 0.05
- body height · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96RR4-F1 | alphafold | PREDICTED | 66.82 | — |
Amino-acid sequence (588 residues)
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKK PTRECESLSE LKEARQRRQP PGHRPAPRGG GGSALVRGSP CVESCWAPAP GSPARMHPLR PEEAMEPE
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