Gamma-tubulin complex component 6 (TUBGCP6)

About Gamma-tubulin complex component 6

Gamma-tubulin complex component 6 (TUBGCP6) is a protein from Homo sapiens identified by UniProt accession Q96RT7, 1819 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.

Target properties

Protein name	Gamma-tubulin complex component 6
UniProt accession	Q96RT7
Gene	TUBGCP6
Organism	Homo sapiens
Length	1819 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (53)

Diseases linked to this target (Open Targets).

microcephaly and chorioretinopathy 1 · score 0.79
genetic disorder · score 0.42
autosomal recessive primary microcephaly · score 0.37
Primary microcephaly · score 0.37
neurodegenerative disease · score 0.27
ovarian cancer · score 0.23
breast adenocarcinoma · score 0.23
acute myeloid leukemia · score 0.15
chronic lymphocytic leukemia · score 0.14
eosinophil count · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96RT7-F1	alphafold	PREDICTED	59.55	—

Amino-acid sequence (1819 residues)

MASITQLFDD LCEALLPAAK THLGQRSVNR KRAKRSLKKV AYNALFTNLF QDETQQLQPD MSKLPARNKI LMLSFDLRVG GLGPKADRLE ELVEELEAAP CCPLLEVGSV LDLLVQLAGS GPPQVLPRKR DYFLNNKHVG RNVPYSGYDC DDLSVFEMDV QSLISREECL CHSMIQETLQ VMEAAPGTGL PTVGLFSFGD PCGDRFERDT RVSLFGALVH SRTYDMDVRL GLPPVPDNAD LSGLAIKVPP SVDQWEDEGF QSASNLTPDS QSEPSVTPDV DLWEAALTYE ASKRRCWERV GCPPGHREEP YLTEAGRDAF DKFCRLHQGE LQLLAGGVLQ APQPVLVKEC ELVKDVLNVL IGVVSATFSL CQPAQAFVVK RGVHVSGASP ESISSLLSEV AEYGTCYTRL SHFSLQPVLD SLYSKGLVFQ AFTSGLRRYL QYYRACVLST PPTLSLLTIG FLFKKLGRQL RYLAELCGVG AVLPGTCGGG PRAAFPTGVK LLSYLYQEAL HNCSNEHYPV LLSLLKTSCE PYTRFIHDWV YSGVFRDAYG EFMIQVNHEY LSFRDKLYWT HGYVLISKEV EDCVPVFLKH IAHDIYVCGK TINLLKLCCP RHYLCWSDVP VPRISVIFSL EELKEIEKDC AVYVGRMERV ARHSSVSKEE KELRMEIAKQ ELIAHAREAA SRVLSALSDR QMSERMALDA RKREQFQRLK EQFVKDQERR QAARQEELDD DFSYARELRD RERRLKSLEE ELERKARQAL VDHYSKLSAE AARREQKALW RIQRHRLESA RLRFLLEDEK HIQEMLKAVS EAHQPQEPPD VLLSVHPQVT SPGPEHPEGG QGCDSGSAEQ HSPAWDGWNR PGLLTPQPLK PLAVGAGGRG LQQAEGARPF SDSLSIGDFL PVGPGAEPSV QTGMVPLLEV ALQTINLDLP PSAPGEAPAA ASTQPSRPQE YDFSTVLRPA VATSPAPGPL QAAECSLGSS GLQLWEDSCG KMDACGSASR ETLLPSHPPR RAALEEGSSQ PTERLFGQVS GGGLPTGDYA SEIAPTRPRW NTHGHVSDAS IRVGENVSDV APTQPRWNTH GHVSNASISL GESVSDVAPT RPRWNIHGHV SNASIRVGEN VSDVAPTRPR WNTHGHVSNA SIRVGENVSD VAPTRPRWNT HGHVSDASIS LGESVSDMAP ARPRWNTHGH VSDASISLGE SVSDMAPTRP RWNTHGHVSD TSIRVGENVS DVAPIRSRCN THGHVSDASI SLGEPVSDVV STRPRWNTHV PIPPPHMVLG ALSPEAEPNT PRPQQSPPGH TSQSALSLGA QSTVLDCGPR LPVEVGPSLS SPSSGCGEGS ISVGENVSDV APTQPWWPNT PGDSVSEELG PGRSGDTEDL SPNWPLNSQE DTAAQSSPGR GEEAEASAAE AQGGEQAYLA GLAGQYHLER YPDSYESMSE PPIAHLLRPV LPRAFAFPVD PQVQSAADET AVQLSELLTL PVLMKRSITA PLAAHISLVN KAAVDYFFVE LHLEAHYEAL RHFLLMEDGE FAQSLSDLLF EKLGAGQTPG ELLNPLVLNS VLSKALQCSL HGDTPHASNL SLALKYLPEV FAPNAPDVLS CLELRYKVDW PLNIVITEGC VSKYSGVFSF LLQLKLMMWA LKDVCFHLKR TALLSHMAGS VQFRQLQLFK HEMQHFVKVI QGYIANQILH VTWCEFRARL ATVGDLEEIQ RAHAEYLHKA VFRGLLTEKA APVMNVIHSI FSLVLKFRSQ LISQAWGPPG GPRGAEHPNF ALMQQSYNTF KYYSHFLFKV VTKLVNRGYQ PHLEDFLLRI NFNNYYQDA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards