About GATOR2 complex protein WDR24
GATOR2 complex protein WDR24 (WDR24) is a protein
from Homo sapiens identified by UniProt accession
Q96S15, 790 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | GATOR2 complex protein WDR24 |
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| UniProt accession | Q96S15 |
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| Gene | WDR24 |
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| Organism | Homo sapiens |
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| Length | 790 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- platelet count · score 0.22
- self reported educational attainment · score 0.21
- smoking status measurement · score 0.15
- smoking initiation · score 0.13
- smoking behavior · score 0.12
- age at first sexual intercourse measurement · score 0.12
- smoking behaviour measurement · score 0.12
- mathematical ability · score 0.12
- attention deficit hyperactivity disorder · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96S15-F1 | alphafold | PREDICTED | 73.35 | — |
Amino-acid sequence (790 residues)
MEKMSRVTTA LGGSVLTGRT MHCHLDAPAN AISVCRDAAQ VVVAGRSIFK IYAIEEEQFV EKLNLRVGRK PSLNLSCADV VWHQMDENLL ATAATNGVVV TWNLGRPSRN KQDQLFTEHK RTVNKVCFHP TEAHVLLSGS QDGFMKCFDL RRKDSVSTFS GQSESVRDVQ FSIRDYFTFA STFENGNVQL WDIRRPDRCE RMFTAHNGPV FCCDWHPEDR GWLATGGRDK MVKVWDMTTH RAKEMHCVQT IASVARVKWR PECRHHLATC SMMVDHNIYV WDVRRPFVPA AMFEEHRDVT TGIAWRHPHD PSFLLSGSKD SSLCQHLFRD ASQPVERANP EGLCYGLFGD LAFAAKESLV AAESGRKPYT GDRRHPIFFK RKLDPAEPFA GLASSALSVF ETEPGGGGMR WFVDTAERYA LAGRPLAELC DHNAKVAREL GRNQVAQTWT MLRIIYCSPG LVPTANLNHS VGKGGSCGLP LMNSFNLKDM APGLGSETRL DRSKGDARSD TVLLDSSATL ITNEDNEETE GSDVPADYLL GDVEGEEDEL YLLDPEHAHP EDPECVLPQE AFPLRHEIVD TPPGPEHLQD KADSPHVSGS EADVASLAPV DSSFSLLSVS HALYDSRLPP DFFGVLVRDM LHFYAEQGDV QMAVSVLIVL GERVRKDIDE QTQEHWYTSY IDLLQRFRLW NVSNEVVKLS TSRAVSCLNQ ASTTLHVNCS HCKRPMSSRG WVCDRCHRCA SMCAVCHHVV KGLFVWCQGC SHGGHLQHIM KWLEGSSHCP AGCGHLCEYS
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