About JmjC domain-containing protein 8
JmjC domain-containing protein 8 (JMJD8) is a protein
from Homo sapiens identified by UniProt accession
Q96S16, 264 residues long.
MolForge cross-references it against 0 known binders and
43 disease associations.
Target properties
| Protein name | JmjC domain-containing protein 8 |
|---|
| UniProt accession | Q96S16 |
|---|
| Gene | JMJD8 |
|---|
| Organism | Homo sapiens |
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| Length | 264 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (43)
Diseases linked to this target (Open Targets).
- spinocerebellar ataxia 48 · score 0.53
- autosomal recessive spinocerebellar ataxia 16 · score 0.52
- genetic disorder · score 0.17
- blood protein measurement · score 0.13
- cancer · score 0.08
- chronotype measurement · score 0.06
- glioblastoma multiforme · score 0.05
- non-small cell lung carcinoma · score 0.05
- platelet count · score 0.05
- hemochromatosis type 5 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96S16-F1 | alphafold | PREDICTED | 90.20 | — |
Amino-acid sequence (264 residues)
MAPASRLLAL WALAAVALPG SGAEGDGGWR PGGPGAVAEE ERCTVERRAD LTYAEFVQQY AFVRPVILQG LTDNSRFRAL CSRDRLLASF GDRVVRLSTA NTYSYHKVDL PFQEYVEQLL HPQDPTSLGN DTLYFFGDNN FTEWASLFRH YSPPPFGLLG TAPAYSFGIA GAGSGVPFHW HGPGYSEVIY GRKRWFLYPP EKTPEFHPNK TTLAWLRDTY PALPPSARPL ECTIRAGEVL YFPDRWWHAT LNLDTSVFIS TFLG
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