Ras-related protein Rab-40C (RAB40C)

About Ras-related protein Rab-40C

Ras-related protein Rab-40C (RAB40C) is a protein from Homo sapiens identified by UniProt accession Q96S21, 281 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.

Target properties

Protein name	Ras-related protein Rab-40C
UniProt accession	Q96S21
Gene	RAB40C
Organism	Homo sapiens
Length	281 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (66)

Diseases linked to this target (Open Targets).

Red cell distribution width · score 0.21
blood protein measurement · score 0.19
mean corpuscular hemoglobin concentration · score 0.17
self reported educational attainment · score 0.14
reticulocyte measurement · score 0.13
cystatin C measurement · score 0.13
cortical surface area measurement · score 0.12
age at first sexual intercourse measurement · score 0.12
reticulocyte count · score 0.11
mean corpuscular hemoglobin · score 0.09

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96S21-F1	alphafold	PREDICTED	74.02	—

Amino-acid sequence (281 residues)

MGSQGSPVKS YDYLLKFLLV GDSDVGKGEI LESLQDGAAE SPYAYSNGID YKTTTILLDG RRVKLELWDT SGQGRFCTIF RSYSRGAQGI LLVYDITNRW SFDGIDRWIK EIDEHAPGVP RILVGNRLHL AFKRQVPTEQ ARAYAEKNCM TFFEVSPLCN FNVIESFTEL SRIVLMRHGM EKIWRPNRVF SLQDLCCRAI VSCTPVHLID KLPLPVTIKS HLKSFSMANG MNAVMMHGRS YSLASGAGGG GSKGNSLKRS KSIRPPQSPP QNCSRSNCKI S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards