Nodal homolog (NODAL)

About Nodal homolog

Nodal homolog (NODAL) is a protein from Homo sapiens identified by UniProt accession Q96S42, 347 residues long. MolForge cross-references it against 0 known binders and 167 disease associations.

Target properties

Protein name	Nodal homolog
UniProt accession	Q96S42
Gene	NODAL
Organism	Homo sapiens
Length	347 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (167)

Diseases linked to this target (Open Targets).

heterotaxy, visceral, 5, autosomal · score 0.76
visceral heterotaxy · score 0.68
Heterotaxia · score 0.64
Situs inversus totalis · score 0.44
congenital heart disease · score 0.38
Abnormal heart morphology · score 0.37
semilobar holoprosencephaly · score 0.37
midline interhemispheric variant of holoprosencephaly · score 0.37
septopreoptic holoprosencephaly · score 0.37
microform holoprosencephaly · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96S42-F1	alphafold	PREDICTED	75.46	—

Amino-acid sequence (347 residues)

MHAHCLPFLL HAWWALLQAG AATVATALLR TRGQPSSPSP LAYMLSLYRD PLPRADIIRS LQAEDVAVDG QNWTFAFDFS FLSQQEDLAW AELRLQLSSP VDLPTEGSLA IEIFHQPKPD TEQASDSCLE RFQMDLFTVT LSQVTFSLGS MVLEVTRPLS KWLKHPGALE KQMSRVAGEC WPRPPTPPAT NVLLMLYSNL SQEQRQLGGS TLLWEAESSW RAQEGQLSWE WGKRHRRHHL PDRSQLCRKV KFQVDFNLIG WGSWIIYPKQ YNAYRCEGEC PNPVGEEFHP TNHAYIQSLL KRYQPHRVPS TCCAPVKTKP LSMLYVDNGR VLLDHHKDMI VEECGCL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards