EKC/KEOPS complex subunit TP53RK (TP53RK)

About EKC/KEOPS complex subunit TP53RK

EKC/KEOPS complex subunit TP53RK (TP53RK) is a protein from Homo sapiens identified by UniProt accession Q96S44, 253 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	EKC/KEOPS complex subunit TP53RK
UniProt accession	Q96S44
Gene	TP53RK
Organism	Homo sapiens
Length	253 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (1)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (60)

Diseases linked to this target (Open Targets).

Galloway-Mowat syndrome · score 0.73
neurodegenerative disease · score 0.43
Global developmental delay · score 0.32
Seizure · score 0.32
glioblastoma multiforme · score 0.25
head and neck squamous cell carcinoma · score 0.18
small cell lung carcinoma · score 0.14
Microcephaly · score 0.11
chronic kidney disease · score 0.08
insulin resistance · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q96S44-F1	alphafold	PREDICTED	91.04	—

Amino-acid sequence (253 residues)

MAAARATTPA DGEEPAPEAE ALAAARERSS RFLSGLELVK QGAEARVFRG RFQGRAAVIK HRFPKGYRHP ALEARLGRRR TVQEARALLR CRRAGISAPV VFFVDYASNC LYMEEIEGSV TVRDYIQSTM ETEKTPQGLS NLAKTIGQVL ARMHDEDLIH GDLTTSNMLL KPPLEQLNIV LIDFGLSFIS ALPEDKGVDL YVLEKAFLST HPNTETVFEA FLKSYSTSSK KARPVLKKLD EVRLRGRKRS MVG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards