About GPI-anchor transamidase component PIGS
GPI-anchor transamidase component PIGS (PIGS) is a protein
from Homo sapiens identified by UniProt accession
Q96S52, 555 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | GPI-anchor transamidase component PIGS |
|---|
| UniProt accession | Q96S52 |
|---|
| Gene | PIGS |
|---|
| Organism | Homo sapiens |
|---|
| Length | 555 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (31)
Diseases linked to this target (Open Targets).
- glycosylphosphatidylinositol biosynthesis defect 18 · score 0.70
- neurodegenerative disease · score 0.26
- genetic disorder · score 0.19
- urate measurement · score 0.03
- platelet count · score 0.03
- reticulocyte count · score 0.03
- insomnia measurement · score 0.03
- platelet crit · score 0.02
- apolipoprotein B measurement · score 0.02
- cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96S52-F1 | alphafold | PREDICTED | 85.48 | — |
Amino-acid sequence (555 residues)
MAAAGAAATH LEVARGKRAA LFFAAVAIVL GLPLWWKTTE TYRASLPYSQ ISGLNALQLR LMVPVTVVFT RESVPLDDQE KLPFTVVHER EIPLKYKMKI KCRFQKAYRR ALDHEEEALS SGSVQEAEAM LDEPQEQAEG SLTVYVISEH SSLLPQDMMS YIGPKRTAVV RGIMHREAFN IIGRRIVQVA QAMSLTEDVL AAALADHLPE DKWSAEKRRP LKSSLGYEIT FSLLNPDPKS HDVYWDIEGA VRRYVQPFLN ALGAAGNFSV DSQILYYAML GVNPRFDSAS SSYYLDMHSL PHVINPVESR LGSSAASLYP VLNFLLYVPE LAHSPLYIQD KDGAPVATNA FHSPRWGGIM VYNVDSKTYN ASVLPVRVEV DMVRVMEVFL AQLRLLFGIA QPQLPPKCLL SGPTSEGLMT WELDRLLWAR SVENLATATT TLTSLAQLLG KISNIVIKDD VASEVYKAVA AVQKSAEELA SGHLASAFVA SQEAVTSSEL AFFDPSLLHL LYFPDDQKFA IYIPLFLPMA VPILLSLVKI FLETRKSWRK PEKTD
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