About Chloride channel CLIC-like protein 1
Chloride channel CLIC-like protein 1 (CLCC1) is a protein
from Homo sapiens identified by UniProt accession
Q96S66, 551 residues long.
MolForge cross-references it against 0 known binders and
345 disease associations.
Target properties
| Protein name | Chloride channel CLIC-like protein 1 |
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| UniProt accession | Q96S66 |
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| Gene | CLCC1 |
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| Organism | Homo sapiens |
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| Length | 551 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (345)
Diseases linked to this target (Open Targets).
- Chudley-McCullough syndrome · score 0.56
- neurodegenerative disease · score 0.54
- retinitis pigmentosa 32 · score 0.50
- Rare genetic deafness · score 0.49
- deafness · score 0.48
- hearing loss, autosomal recessive · score 0.46
- genetic disorder · score 0.41
- lysosomal storage disease · score 0.37
- Hearing impairment · score 0.12
- axial length measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96S66-F1 | alphafold | PREDICTED | 60.42 | — |
Amino-acid sequence (551 residues)
MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG EKDVSPDLSC ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY LNKILIEAGK LGLPDENKGD MHYDAEIILK RETLLEIQKF LNGEDWKPGA LDDALSDILI NFKFHDFETW KWRFEDSFGV DPYNVLMVLL CLLCIVVLVA TELWTYVRWY TQLRRVLIIS FLFSLGWNWM YLYKLAFAQH QAEVAKMEPL NNVCAKKMDW TGSIWEWFRS SWTYKDDPCQ KYYELLLVNP IWLVPPTKAL AVTFTTFVTE PLKHIGKGTG EFIKALMKEI PALLHLPVLI IMALAILSFC YGAGKSVHVL RHIGGPESEP PQALRPRDRR RQEEIDYRPD GGAGDADFHY RGQMGPTEQG PYAKTYEGRR EILRERDVDL RFQTGNKSPE VLRAFDVPDA EAREHPTVVP SHKSPVLDTK PKETGGILGE GTPKESSTES SQSAKPVSGQ DTSGNTEGSP AAEKAQLKSE AAGSPDQGST YSPARGVAGP RGQDPVSSPC G
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