About Pleckstrin homology domain-containing family F member 1
Pleckstrin homology domain-containing family F member 1 (PLEKHF1) is a protein
from Homo sapiens identified by UniProt accession
Q96S99, 279 residues long.
MolForge cross-references it against 0 known binders and
44 disease associations.
Target properties
| Protein name | Pleckstrin homology domain-containing family F member 1 |
|---|
| UniProt accession | Q96S99 |
|---|
| Gene | PLEKHF1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 279 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (44)
Diseases linked to this target (Open Targets).
- body mass index · score 0.04
- cancer · score 0.04
- protein measurement · score 0.03
- metabolite measurement · score 0.03
- calcium measurement · score 0.03
- body height · score 0.03
- gait measurement · score 0.02
- drug use measurement · score 0.02
- heart rate response to exercise · score 0.02
- pulmonary fibrosis · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96S99-F1 | alphafold | PREDICTED | 85.27 | — |
Amino-acid sequence (279 residues)
MVDHLANTEI NSQRIAAVES CFGASGQPLA LPGRVLLGEG VLTKECRKKA KPRIFFLFND ILVYGSIVLN KRKYRSQHII PLEEVTLELL PETLQAKNRW MIKTAKKSFV VSAASATERQ EWISHIEECV RRQLRATGRP PSTEHAAPWI PDKATDICMR CTQTRFSALT RRHHCRKCGF VVCAECSRQR FLLPRLSPKP VRVCSLCYRE LAAQQRQEEA EEQGAGSPGQ PAHLARPICG ASSGDDDDSD EDKEGSRDGD WPSSVEFYAS GVAWSAFHS
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