About SRSF protein kinase 1
SRSF protein kinase 1 (SRPK1) is a protein
from Homo sapiens identified by UniProt accession
Q96SB4, 655 residues long.
MolForge cross-references it against 0 known binders and
139 disease associations.
Target properties
| Protein name | SRSF protein kinase 1 |
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| UniProt accession | Q96SB4 |
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| Gene | SRPK1 |
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| Organism | Homo sapiens |
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| Length | 655 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (11)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (139)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- COVID-19 · score 0.37
- mean corpuscular volume · score 0.34
- mean corpuscular hemoglobin · score 0.32
- age at menopause · score 0.31
- mean corpuscular hemoglobin concentration · score 0.28
- reticulocyte measurement · score 0.27
- mean reticulocyte volume · score 0.20
- reticulocyte count · score 0.19
- urate measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96SB4-F1 | alphafold | PREDICTED | 70.89 | — |
Amino-acid sequence (655 residues)
MERKVLALQA RKKRTKAKKD KAQRKSETQH RGSAPHSESD LPEQEEEILG SDDDEQEDPN DYCKGGYHLV KIGDLFNGRY HVIRKLGWGH FSTVWLSWDI QGKKFVAMKV VKSAEHYTET ALDEIRLLKS VRNSDPNDPN REMVVQLLDD FKISGVNGTH ICMVFEVLGH HLLKWIIKSN YQGLPLPCVK KIIQQVLQGL DYLHTKCRII HTDIKPENIL LSVNEQYIRR LAAEATEWQR SGAPPPSGSA VSTAPQPKPA DKMSKNKKKK LKKKQKRQAE LLEKRMQEIE EMEKESGPGQ KRPNKQEESE SPVERPLKEN PPNKMTQEKL EESSTIGQDQ TLMERDTEGG AAEINCNGVI EVINYTQNSN NETLRHKEDL HNANDCDVQN LNQESSFLSS QNGDSSTSQE TDSCTPITSE VSDTMVCQSS STVGQSFSEQ HISQLQESIR AEIPCEDEQE QEHNGPLDNK GKSTAGNFLV NPLEPKNAEK LKVKIADLGN ACWVHKHFTE DIQTRQYRSL EVLIGSGYNT PADIWSTACM AFELATGDYL FEPHSGEEYT RDEDHIALII ELLGKVPRKL IVAGKYSKEF FTKKGDLKHI TKLKPWGLFE VLVEKYEWSQ EEAAGFTDFL LPMLELIPEK RATAAECLRH PWLNS
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