About Doublesex- and mab-3-related transcription factor A2
Doublesex- and mab-3-related transcription factor A2 (DMRTA2) is a protein
from Homo sapiens identified by UniProt accession
Q96SC8, 542 residues long.
MolForge cross-references it against 0 known binders and
65 disease associations.
Target properties
| Protein name | Doublesex- and mab-3-related transcription factor A2 |
|---|
| UniProt accession | Q96SC8 |
|---|
| Gene | DMRTA2 |
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| Organism | Homo sapiens |
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| Length | 542 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (65)
Diseases linked to this target (Open Targets).
- serum alanine aminotransferase measurement · score 0.36
- smoking status measurement · score 0.30
- pulse pressure measurement · score 0.29
- attention deficit hyperactivity disorder · score 0.28
- antisocial behaviour measurement · score 0.28
- substance abuse · score 0.28
- serum gamma-glutamyl transferase measurement · score 0.22
- cortical thickness · score 0.20
- androgenetic alopecia · score 0.17
- urate measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96SC8-F1 | alphafold | PREDICTED | 55.82 | — |
Amino-acid sequence (542 residues)
MELRSELPSV PGAATAAAAT ATGPPVASVA SVAAAAAAAA SLPVSVAGGL LRGPPLLLRA AEKYPRTPKC ARCRNHGVVS ALKGHKRYCR WKDCLCAKCT LIAERQRVMA AQVALRRQQA QEENEARELQ LLYGTAEGLA LAAANGIIPP RPAYEVFGSV CAADGGGPGA GAPAGTGGGA AGAGGSEAKL QKFDLFPKTL LQAGRPGSPL PPPVKPLSPD GADSGPGTSS PEVRPGSGSE NGDGESFSGS PLARASKEAG GSCPGSAGPG GGGEEDSPGS ASPLGSESGS EADKEEGEAA PAPGLGGGSG PRQRTPLDIL TRVFPGHRRG VLELVLQGCG GDVVQAIEQV LNHHRGGLAA GLGPAAPPDK AAVGAAAAAD DAWPSRVDAA AAAAAAAGGP GLPAPLQAGP AAPPHHRPLL AGAMAPGALG SLSSRSAFSP LQPNASHFGA DAGAYPLGAP LGLSPLRLAY SAAAAHSRGL AFMAPYSTAG LVPTLGFRPP MDYAFSDLMR DRSAAAAAAV HKEPTYGGGL YGPMVNGAPE KQ
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