About Protein orai-2
Protein orai-2 (ORAI2) is a protein
from Homo sapiens identified by UniProt accession
Q96SN7, 254 residues long.
MolForge cross-references it against 0 known binders and
78 disease associations.
Target properties
| Protein name | Protein orai-2 |
|---|
| UniProt accession | Q96SN7 |
|---|
| Gene | ORAI2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 254 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (78)
Diseases linked to this target (Open Targets).
- diabetes mellitus · score 0.33
- chronotype measurement · score 0.32
- type 2 diabetes mellitus · score 0.32
- breast adenocarcinoma · score 0.26
- glioblastoma multiforme · score 0.22
- endometrial cancer · score 0.21
- ovarian cancer · score 0.18
- insomnia measurement · score 0.14
- thyroid gland adenocarcinoma · score 0.12
- cutaneous melanoma · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96SN7-F1 | alphafold | PREDICTED | 80.12 | — |
Amino-acid sequence (254 residues)
MSAELNVPID PSAPACPEPG HKGMDYRDWV RRSYLELVTS NHHSVQALSW RKLYLSRAKL KASSRTSALL SGFAMVAMVE VQLETQYQYP RPLLIAFSAC TTVLVAVHLF ALLISTCILP NVEAVSNIHN LNSISESPHE RMHPYIELAW GFSTVLGILL FLAEVVLLCW IKFLPVDARR QPGPPPGPGS HTGWQAALVS TIIMVPVGLI FVVFTIHFYR SLVRHKTERH NREIEELHKL KVQLDGHERS LQVL
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