About Protein cereblon
Protein cereblon (CRBN) is a protein
from Homo sapiens identified by UniProt accession
Q96SW2, 442 residues long.
MolForge cross-references it against 0 known binders and
361 disease associations.
Target properties
| Protein name | Protein cereblon |
|---|
| UniProt accession | Q96SW2 |
|---|
| Gene | CRBN |
|---|
| Organism | Homo sapiens |
|---|
| Length | 442 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (5)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (361)
Diseases linked to this target (Open Targets).
- multiple myeloma · score 0.70
- autosomal recessive non-syndromic intellectual disability · score 0.60
- congenital sideroblastic anemia-B-cell immunodeficiency-periodic fever-developmental delay syndrome · score 0.57
- myelodysplastic syndrome · score 0.56
- Mantle cell lymphoma · score 0.55
- immune system disease · score 0.50
- retinitis pigmentosa and erythrocytic microcytosis · score 0.50
- lymphoma · score 0.48
- AL amyloidosis · score 0.48
- acute myeloid leukemia · score 0.47
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96SW2-F1 | alphafold | PREDICTED | 86.60 | — |
Amino-acid sequence (442 residues)
MAGEGDQQDA AHNMGNHLPL LPAESEEEDE MEVEDQDSKE AKKPNIINFD TSLPTSHTYL GADMEEFHGR TLHDDDSCQV IPVLPQVMMI LIPGQTLPLQ LFHPQEVSMV RNLIQKDRTF AVLAYSNVQE REAQFGTTAE IYAYREEQDF GIEIVKVKAI GRQRFKVLEL RTQSDGIQQA KVQILPECVL PSTMSAVQLE SLNKCQIFPS KPVSREDQCS YKWWQKYQKR KFHCANLTSW PRWLYSLYDA ETLMDRIKKQ LREWDENLKD DSLPSNPIDF SYRVAACLPI DDVLRIQLLK IGSAIQRLRC ELDIMNKCTS LCCKQCQETE ITTKNEIFSL SLCGPMAAYV NPHGYVHETL TVYKACNLNL IGRPSTEHSW FPGYAWTVAQ CKICASHIGW KFTATKKDMS PQKFWGLTRS ALLPTIPDTE DEISPDKVIL CL
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