About 2-aminoethanethiol dioxygenase
2-aminoethanethiol dioxygenase (ADO) is a protein
from Homo sapiens identified by UniProt accession
Q96SZ5, 270 residues long.
MolForge cross-references it against 0 known binders and
193 disease associations.
Target properties
| Protein name | 2-aminoethanethiol dioxygenase |
|---|
| UniProt accession | Q96SZ5 |
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| Gene | ADO |
|---|
| Organism | Homo sapiens |
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| Length | 270 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (193)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.41
- diastolic blood pressure · score 0.40
- systolic blood pressure · score 0.39
- eosinophil percentage of leukocytes · score 0.39
- monocyte count · score 0.37
- FEV/FVC ratio · score 0.33
- red blood cell density measurement · score 0.32
- hypertension · score 0.32
- lymphocyte count · score 0.32
- cardiovascular disease · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96SZ5-F1 | alphafold | PREDICTED | 86.13 | — |
Amino-acid sequence (270 residues)
MPRDNMASLI QRIARQACLT FRGSGGGRGA SDRDAASGPE APMQPGFPEN LSKLKSLLTQ LRAEDLNIAP RKATLQPLPP NLPPVTYMHI YETDGFSLGV FLLKSGTSIP LHDHPGMHGM LKVLYGTVRI SCMDKLDAGG GQRPRALPPE QQFEPPLQPR EREAVRPGVL RSRAEYTEAS GPCILTPHRD NLHQIDAVEG PAAFLDILAP PYDPDDGRDC HYYRVLEPVR PKEASSSACD LPREVWLLET PQADDFWCEG EPYPGPKVFP
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