About Bifunctional polynucleotide phosphatase/kinase
Bifunctional polynucleotide phosphatase/kinase (PNKP) is a protein
from Homo sapiens identified by UniProt accession
Q96T60, 521 residues long.
MolForge cross-references it against 0 known binders and
100 disease associations.
Target properties
| Protein name | Bifunctional polynucleotide phosphatase/kinase |
|---|
| UniProt accession | Q96T60 |
|---|
| Gene | PNKP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 521 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (100)
Diseases linked to this target (Open Targets).
- microcephaly, seizures, and developmental delay · score 0.81
- Ataxia-oculomotor apraxia type 4 · score 0.79
- Spinocerebellar ataxia with axonal neuropathy type 2 · score 0.71
- developmental and epileptic encephalopathy · score 0.66
- Charcot-Marie-Tooth disease type 2B2 · score 0.59
- developmental and epileptic encephalopathy, 12 · score 0.56
- genetic disorder · score 0.54
- Abnormality of the nervous system · score 0.45
- Intellectual disability · score 0.34
- ataxia, early-onset, with oculomotor apraxia and hypoalbuminemia · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96T60-F1 | alphafold | PREDICTED | 90.94 | — |
Amino-acid sequence (521 residues)
MGEVEAPGRL WLESPPGGAP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRTQ VELVADPETR TVAVKQLGVN PSTTGTQELK PGLEGSLGVG DTLYLVNGLH PLTLRWEETR TPESQPDTPP GTPLVSQDEK RDAELPKKRM RKSNPGWENL EKLLVFTAAG VKPQGKVAGF DLDGTLITTR SGKVFPTGPS DWRILYPEIP RKLRELEAEG YKLVIFTNQM SIGRGKLPAE EFKAKVEAVV EKLGVPFQVL VATHAGLYRK PVTGMWDHLQ EQANDGTPIS IGDSIFVGDA AGRPANWAPG RKKKDFSCAD RLFALNLGLP FATPEEFFLK WPAAGFELPA FDPRTVSRSG PLCLPESRAL LSASPEVVVA VGFPGAGKST FLKKHLVSAG YVHVNRDTLG SWQRCVTTCE TALKQGKRVA IDNTNPDAAS RARYVQCARA AGVPCRCFLF TATLEQARHN NRFREMTDSS HIPVSDMVMY GYRKQFEAPT LAEGFSAILE IPFRLWVEPR LGRLYCQFSE G
Explore Bifunctional polynucleotide phosphatase/kinase with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets