About Histone-lysine N-methyltransferase SETDB2
Histone-lysine N-methyltransferase SETDB2 (SETDB2) is a protein
from Homo sapiens identified by UniProt accession
Q96T68, 719 residues long.
MolForge cross-references it against 0 known binders and
109 disease associations.
Target properties
| Protein name | Histone-lysine N-methyltransferase SETDB2 |
|---|
| UniProt accession | Q96T68 |
|---|
| Gene | SETDB2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 719 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (109)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.41
- neurodegenerative disease · score 0.31
- vital capacity · score 0.25
- breast adenocarcinoma · score 0.24
- Immunodeficiency due to a late component of complements deficiency · score 0.08
- lung adenocarcinoma · score 0.08
- platelet count · score 0.07
- acute myeloid leukemia · score 0.07
- X-linked severe congenital neutropenia · score 0.07
- acute respiratory distress syndrome · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96T68-F1 | alphafold | PREDICTED | 62.36 | — |
Amino-acid sequence (719 residues)
MGEKNGDAKT FWMELEDDGK VDFIFEQVQN VLQSLKQKIK DGSATNKEYI QAMILVNEAT IINSSTSIKG ASQKEVNAQS SDPMPVTQKE QENKSNAFPS TSCENSFPED CTFLTTENKE ILSLEDKVVD FREKDSSSNL SYQSHDCSGA CLMKMPLNLK GENPLQLPIK CHFQRRHAKT NSHSSALHVS YKTPCGRSLR NVEEVFRYLL ETECNFLFTD NFSFNTYVQL ARNYPKQKEV VSDVDISNGV ESVPISFCNE IDSRKLPQFK YRKTVWPRAY NLTNFSSMFT DSCDCSEGCI DITKCACLQL TARNAKTSPL SSDKITTGYK YKRLQRQIPT GIYECSLLCK CNRQLCQNRV VQHGPQVRLQ VFKTEQKGWG VRCLDDIDRG TFVCIYSGRL LSRANTEKSY GIDENGRDEN TMKNIFSKKR KLEVACSDCE VEVLPLGLET HPRTAKTEKC PPKFSNNPKE LTVETKYDNI SRIQYHSVIR DPESKTAIFQ HNGKKMEFVS SESVTPEDND GFKPPREHLN SKTKGAQKDS SSNHVDEFED NLLIESDVID ITKYREETPP RSRCNQATTL DNQNIKKAIE VQIQKPQEGR STACQRQQVF CDEELLSETK NTSSDSLTKF NKGNVFLLDA TKEGNVGRFL NHSCCPNLLV QNVFVETHNR NFPLVAFFTN RYVKARTELT WDYGYEAGTV PEKEIFCQCG VNKCRKKIL
Explore Histone-lysine N-methyltransferase SETDB2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets