About Sodium/hydrogen exchanger 7
Sodium/hydrogen exchanger 7 (SLC9A7) is a protein
from Homo sapiens identified by UniProt accession
Q96T83, 725 residues long.
MolForge cross-references it against 0 known binders and
29 disease associations.
Target properties
| Protein name | Sodium/hydrogen exchanger 7 |
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| UniProt accession | Q96T83 |
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| Gene | SLC9A7 |
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| Organism | Homo sapiens |
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| Length | 725 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (29)
Diseases linked to this target (Open Targets).
- X-linked syndromic intellectual disability · score 0.38
- X-linked non-syndromic intellectual disability · score 0.37
- mental or behavioural disorder · score 0.21
- cutaneous melanoma · score 0.13
- neoplasm · score 0.08
- hepatocellular carcinoma · score 0.07
- ulcerative colitis · score 0.02
- non-small cell lung carcinoma · score 0.01
- X-linked intellectual disability · score 0.01
- Intellectual disability · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q96T83-F1 | alphafold | PREDICTED | 67.14 | — |
Amino-acid sequence (725 residues)
MEPGDAARPG SGRATGAPPP RLLLLPLLLG WGLRVAAAAS ASSSGAAAED SSAMEELATE KEAEESHRQD SVSLLTFILL LTLTILTIWL FKHRRVRFLH ETGLAMIYGL IVGVILRYGT PATSGRDKSL SCTQEDRAFS TLLVNVSGKF FEYTLKGEIS PGKINSVEQN DMLRKVTFDP EVFFNILLPP IIFHAGYSLK KRHFFRNLGS ILAYAFLGTA VSCFIIGNLM YGVVKLMKIM GQLSDKFYYT DCLFFGAIIS ATDPVTVLAI FNELHADVDL YALLFGESVL NDAVAIVLSS SIVAYQPAGL NTHAFDAAAF FKSVGIFLGI FSGSFTMGAV TGVNANVTKF TKLHCFPLLE TALFFLMSWS TFLLAEACGF TGVVAVLFCG ITQAHYTYNN LSVESRSRTK QLFEVLHFLA ENFIFSYMGL ALFTFQKHVF SPIFIIGAFV AIFLGRAAHI YPLSFFLNLG RRHKIGWNFQ HMMMFSGLRG AMAFALAIRD TASYARQMMF TTTLLIVFFT VWIIGGGTTP MLSWLNIRVG VEEPSEEDQN EHHWQYFRVG VDPDQDPPPN NDSFQVLQGD GPDSARGNRT KQESAWIFRL WYSFDHNYLK PILTHSGPPL TTTLPAWCGL LARCLTSPQV YDNQEPLREE DSDFILTEGD LTLTYGDSTV TANGSSSSHT ASTSLEGSRR TKSSSEEVLE RDLGMGDQKV SSRGTRLVFP LEDNA
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