About Proheparin-binding EGF-like growth factor
Proheparin-binding EGF-like growth factor (HBEGF) is a protein
from Homo sapiens identified by UniProt accession
Q99075, 208 residues long.
MolForge cross-references it against 0 known binders and
582 disease associations.
Target properties
| Protein name | Proheparin-binding EGF-like growth factor |
|---|
| UniProt accession | Q99075 |
|---|
| Gene | HBEGF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 208 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (582)
Diseases linked to this target (Open Targets).
- cancer · score 0.60
- diphtheria · score 0.53
- white matter microstructure measurement · score 0.39
- body mass index · score 0.34
- lung adenocarcinoma · score 0.31
- breast adenocarcinoma · score 0.30
- cutaneous melanoma · score 0.28
- creatine kinase measurement · score 0.27
- Alzheimer disease · score 0.18
- white matter integrity · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99075-F1 | alphafold | PREDICTED | 66.47 | — |
Amino-acid sequence (208 residues)
MKLLPSVVLK LFLAAVLSAL VTGESLERLR RGLAAGTSNP DPPTVSTDQL LPLGGGRDRK VRDLQEADLD LLRVTLSSKP QALATPNKEE HGKRKKKGKG LGKKRDPCLR KYKDFCIHGE CKYVKELRAP SCICHPGYHG ERCHGLSLPV ENRLYTYDHT TILAVVAVVL SSVCLLVIVG LLMFRYHRRG GYDVENEEKV KLGMTNSH
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