About Glutamate decarboxylase 1
Glutamate decarboxylase 1 (GAD1) is a protein
from Homo sapiens identified by UniProt accession
Q99259, 594 residues long.
MolForge cross-references it against 0 known binders and
633 disease associations.
Target properties
| Protein name | Glutamate decarboxylase 1 |
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| UniProt accession | Q99259 |
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| Gene | GAD1 |
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| Organism | Homo sapiens |
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| Length | 594 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (633)
Diseases linked to this target (Open Targets).
- developmental and epileptic encephalopathy 89 · score 0.64
- Inherited congenital spastic tetraplegia · score 0.59
- neurodevelopmental disorder with progressive spasticity and brain white matter abnormalities · score 0.53
- cognitive function measurement · score 0.39
- sex hormone-binding globulin measurement · score 0.38
- developmental and epileptic encephalopathy · score 0.37
- mathematical ability · score 0.36
- C-reactive protein measurement · score 0.31
- intelligence · score 0.29
- self reported educational attainment · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99259-F1 | alphafold | PREDICTED | 88.69 | — |
Amino-acid sequence (594 residues)
MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF LQRTNSLEEK SRLVSAFKER QSSKNLLSCE NSDRDARFRR TETDFSNLFA RDLLPAKNGE EQTVQFLLEV VDILLNYVRK TFDRSTKVLD FHHPHQLLEG MEGFNLELSD HPESLEQILV DCRDTLKYGV RTGHPRFFNQ LSTGLDIIGL AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS SKDGDGIFSP GGAISNMYSI MAARYKYFPE VKTKGMAAVP KLVLFTSEQS HYSIKKAGAA LGFGTDNVIL IKCNERGKII PADFEAKILE AKQKGYVPFY VNATAGTTVY GAFDPIQEIA DICEKYNLWL HVDAAWGGGL LMSRKHRHKL NGIERANSVT WNPHKMMGVL LQCSAILVKE KGILQGCNQM CAGYLFQPDK QYDVSYDTGD KAIQCGRHVD IFKFWLMWKA KGTVGFENQI NKCLELAEYL YAKIKNREEF EMVFNGEPEH TNVCFWYIPQ SLRGVPDSPQ RREKLHKVAP KIKALMMESG TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL
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