Cytohesin-2 (CYTH2)

About Cytohesin-2

Cytohesin-2 (CYTH2) is a protein from Homo sapiens identified by UniProt accession Q99418, 400 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Cytohesin-2
UniProt accession	Q99418
Gene	CYTH2
Organism	Homo sapiens
Length	400 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
mean platelet volume · score 0.08
X-linked severe congenital neutropenia · score 0.04
Blackfan-Diamond anemia · score 0.04
neutropenia, severe congenital, 1, autosomal dominant · score 0.04
neutropenia, severe congenital, 2, autosomal dominant · score 0.04
Felty's syndrome · score 0.04
combined immunodeficiency due to moesin deficiency · score 0.04
nonimmune chronic idiopathic neutropenia of adults · score 0.04
agammaglobulinemia 7, autosomal recessive · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99418-F1	alphafold	PREDICTED	84.61	—

Amino-acid sequence (400 residues)

MEDGVYEPPD LTPEERMELE NIRRRKQELL VEIQRLREEL SEAMSEVEGL EANEGSKTLQ RNRKMAMGRK KFNMDPKKGI QFLVENELLQ NTPEEIARFL YKGEGLNKTA IGDYLGEREE LNLAVLHAFV DLHEFTDLNL VQALRQFLWS FRLPGEAQKI DRMMEAFAQR YCLCNPGVFQ STDTCYVLSF AVIMLNTSLH NPNVRDKPGL ERFVAMNRGI NEGGDLPEEL LRNLYDSIRN EPFKIPEDDG NDLTHTFFNP DREGWLLKLG GGRVKTWKRR WFILTDNCLY YFEYTTDKEP RGIIPLENLS IREVDDPRKP NCFELYIPNN KGQLIKACKT EADGRVVEGN HMVYRISAPT QEEKDEWIKS IQAAVSVDPF YEMLAARKKR ISVKKKQEQP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards