About Peroxisomal acyl-coenzyme A oxidase 2
Peroxisomal acyl-coenzyme A oxidase 2 (ACOX2) is a protein
from Homo sapiens identified by UniProt accession
Q99424, 681 residues long.
MolForge cross-references it against 0 known binders and
95 disease associations.
Target properties
| Protein name | Peroxisomal acyl-coenzyme A oxidase 2 |
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| UniProt accession | Q99424 |
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| Gene | ACOX2 |
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| Organism | Homo sapiens |
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| Length | 681 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (95)
Diseases linked to this target (Open Targets).
- Disorder of bile acid synthesis · score 0.64
- serum non-albumin protein measurement · score 0.23
- blood protein measurement · score 0.23
- aspartate aminotransferase measurement · score 0.21
- serum alanine aminotransferase measurement · score 0.08
- total blood protein measurement · score 0.06
- hepatocellular carcinoma · score 0.06
- cholangiocarcinoma · score 0.05
- gallbladder disease · score 0.05
- Congenital bile acid synthesis defect type 3 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99424-F1 | alphafold | PREDICTED | 94.41 | — |
Amino-acid sequence (681 residues)
MGSPVHRVSL GDTWSRQMHP DIESERYMQS FDVERLTNIL DGGAQNTALR RKVESIIHSY PEFSCKDNYF MTQNERYKAA MRRAFHIRLI ARRLGWLEDG RELGYAYRAL SGDVALNIHR VFVRALRSLG SEEQIAKWDP LCKNIQIIAT YAQTELGHGT YLQGLETEAT YDAATQEFVI HSPTLTATKW WPGDLGRSAT HALVQAQLIC SGARRGMHAF IVPIRSLQDH TPLPGIIIGD IGPKMDFDQT DNGFLQLNHV RVPRENMLSR FAQVLPDGTY VKLGTAQSNY LPMVVVRVEL LSGEILPILQ KACVIAMRYS VIRRQSRLRP SDPEAKVLDY QTQQQKLFPQ LAISYAFHFL AVSLLEFFQH SYTAILNQDF SFLPELHALS TGMKAMMSEF CTQGAEMCRR ACGGHGYSKL SGLPSLVTKL SASCTYEGEN TVLYLQVARF LVKSYLQTQM SPGSTPQRSL SPSVAYLTAP DLARCPAQRA ADFLCPELYT TAWAHVAVRL IKDSVQHLQT LTQSGADQHE AWNQTTVIHL QAAKVHCYYV TVKGFTEALE KLENEPAIQQ VLKRLCDLHA IHGILTNSGD FLHDAFLSGA QVDMARTAYL DLLRLIRKDA ILLTDAFDFT DQCLNSALGC YDGNVYERLF QWAQKSPTNT QENPAYEEYI RPLLQSWRSK L
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