About V-type proton ATPase 21 kDa proteolipid subunit c''
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B) is a protein
from Homo sapiens identified by UniProt accession
Q99437, 205 residues long.
MolForge cross-references it against 0 known binders and
40 disease associations.
Target properties
| Protein name | V-type proton ATPase 21 kDa proteolipid subunit c'' |
|---|
| UniProt accession | Q99437 |
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| Gene | ATP6V0B |
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| Organism | Homo sapiens |
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| Length | 205 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (40)
Diseases linked to this target (Open Targets).
- breast adenocarcinoma · score 0.21
- IGF-1 measurement · score 0.20
- blood protein measurement · score 0.20
- self reported educational attainment · score 0.14
- schizophrenia · score 0.13
- intelligence · score 0.13
- cognitive function measurement · score 0.13
- age at first sexual intercourse measurement · score 0.08
- age at first birth measurement · score 0.06
- C-reactive protein measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99437-F1 | alphafold | PREDICTED | 92.67 | — |
Amino-acid sequence (205 residues)
MTGLALLYSG VFVAFWACAL AVGVCYTIFD LGFRFDVAWF LTETSPFMWS NLGIGLAISL SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV AIYGIIMAIV ISNMAEPFSA TDPKAIGHRN YHAGYSMFGA GLTVGLSNLF CGVCVGIVGS GAALADAQNP SLFVKILIVE IFGSAIGLFG VIVAILQTSR VKMGD
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