About Calponin-2
Calponin-2 (CNN2) is a protein
from Homo sapiens identified by UniProt accession
Q99439, 309 residues long.
MolForge cross-references it against 0 known binders and
138 disease associations.
Target properties
| Protein name | Calponin-2 |
|---|
| UniProt accession | Q99439 |
|---|
| Gene | CNN2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 309 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (138)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.33
- neutrophil count · score 0.31
- leukocyte count · score 0.31
- Red cell distribution width · score 0.29
- myeloid white cell count · score 0.28
- eosinophil percentage of leukocytes · score 0.27
- eosinophil count · score 0.26
- mean platelet volume · score 0.24
- gut microbiome measurement · score 0.22
- platelet crit · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99439-F1 | alphafold | PREDICTED | 68.22 | — |
Amino-acid sequence (309 residues)
MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRTWIEG LTGLSIGPDF QKGLKDGTIL CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM NPVDLFEAND LFESGNMTQV QVSLLALAGK AKTKGLQSGV DIGVKYSEKQ ERNFDDATMK AGQCVIGLQM GTNKCASQSG MTAYGTRRHL YDPKNHILPP MDHSTISLQM GTNKCASQVG MTAPGTRRHI YDTKLGTDKC DNSSMSLQMG YTQGANQSGQ VFGLGRQIYD PKYCPQGTVA DGAPSGTGDC PDPGEVPEYP PYYQEEAGY
Explore Calponin-2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets