Ethanolamine-phosphate cytidylyltransferase (PCYT2)

About Ethanolamine-phosphate cytidylyltransferase

Ethanolamine-phosphate cytidylyltransferase (PCYT2) is a protein from Homo sapiens identified by UniProt accession Q99447, 389 residues long. MolForge cross-references it against 0 known binders and 65 disease associations.

Target properties

Protein name	Ethanolamine-phosphate cytidylyltransferase
UniProt accession	Q99447
Gene	PCYT2
Organism	Homo sapiens
Length	389 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (65)

Diseases linked to this target (Open Targets).

spastic paraplegia 82, autosomal recessive · score 0.73
complex hereditary spastic paraplegia · score 0.55
neurodegenerative disease · score 0.54
Global developmental delay · score 0.46
Intellectual disability · score 0.46
Seizure · score 0.46
Developmental regression · score 0.46
Cerebellar atrophy · score 0.46
Spastic paraparesis · score 0.46
Cerebral atrophy · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99447-F1	alphafold	PREDICTED	86.08	—

Amino-acid sequence (389 residues)

MIRNGRGAAG GAEQPGPGGR RAVRVWCDGC YDMVHYGHSN QLRQARAMGD YLIVGVHTDE EIAKHKGPPV FTQEERYKMV QAIKWVDEVV PAAPYVTTLE TLDKYNCDFC VHGNDITLTV DGRDTYEEVK QAGRYRECKR TQGVSTTDLV GRMLLVTKAH HSSQEMSSEY REYADSFGKC PGGRNPWTGV SQFLQTSQKI IQFASGKEPQ PGETVIYVAG AFDLFHIGHV DFLEKVHRLA ERPYIIAGLH FDQEVNHYKG KNYPIMNLHE RTLSVLACRY VSEVVIGAPY AVTAELLSHF KVDLVCHGKT EIIPDRDGSD PYQEPKRRGI FRQIDSGSNL TTDLIVQRII TNRLEYEARN QKKEAKELAF LEAARQQAAQ PLGERDGDF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards