Paired mesoderm homeobox protein 2B (PHOX2B)

About Paired mesoderm homeobox protein 2B

Paired mesoderm homeobox protein 2B (PHOX2B) is a protein from Homo sapiens identified by UniProt accession Q99453, 314 residues long. MolForge cross-references it against 0 known binders and 227 disease associations.

Target properties

Protein name	Paired mesoderm homeobox protein 2B
UniProt accession	Q99453
Gene	PHOX2B
Organism	Homo sapiens
Length	314 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99453-F1	alphafold	PREDICTED	59.79	—

Amino-acid sequence (314 residues)

MYKMEYSYLN SSAYESCMAG MDTSSLASAY ADFSSCSQAS GFQYNPIRTT FGATSGCPSL TPGSCSLGTL RDHQSSPYAA VPYKLFTDHG GLNEKRKQRR IRTTFTSAQL KELERVFAET HYPDIYTREE LALKIDLTEA RVQVWFQNRR AKFRKQERAA AAAAAAAKNG SSGKKSDSSR DDESKEAKST DPDSTGGPGP NPNPTPSCGA NGGGGGGPSP AGAPGAAGPG GPGGEPGKGG AAAAAAAAAA AAAAAAAAAA GGLAAAGGPG QGWAPGPGPI TSIPDSLGGP FASVLSSLQR PNGAKAALVK SSMF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards