SH3 and cysteine-rich domain-containing protein (STAC)

About SH3 and cysteine-rich domain-containing protein

SH3 and cysteine-rich domain-containing protein (STAC) is a protein from Homo sapiens identified by UniProt accession Q99469, 402 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.

Target properties

Protein name	SH3 and cysteine-rich domain-containing protein
UniProt accession	Q99469
Gene	STAC
Organism	Homo sapiens
Length	402 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (28)

Diseases linked to this target (Open Targets).

hemoglobin measurement · score 0.35
response to placebo · score 0.26
adverse effect · score 0.09
Hypoglycemia · score 0.09
psychotic symptom measurement · score 0.06
PHF-tau measurement · score 0.06
Myalgia · score 0.05
red blood cell density measurement · score 0.04
non-small cell lung carcinoma · score 0.03
protein measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99469-F1	alphafold	PREDICTED	65.89	—

Amino-acid sequence (402 residues)

MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK SLRSKSADNF FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG LHPGGKAHAF QEYIFKKPTF CDVCNHMIVG TNAKHGLRCK ACKMSIHHKC TDGLAPQRCM GKLPKGFRRY YSSPLLIHEQ FGCIKEVMPI ACGNKVDPVY ETLRFGTSLA QRTKKGSSGS GSDSPHRTST SDLVEVPEEA NGPGGGYDLR KRSNSVFTYP ENGTDDFRDP AKNINHQGSL SKDPLQMNTY VALYKFVPQE NEDLEMRPGD IITLLEDSNE DWWKGKIQDR IGFFPANFVQ RLQQNEKIFR CVRTFIGCKE QGQITLKENQ ICVSSEEEQD GFIRVLSGKK KGLIPLDVLE NI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards