Prefoldin subunit 5 (PFDN5)

About Prefoldin subunit 5

Prefoldin subunit 5 (PFDN5) is a protein from Homo sapiens identified by UniProt accession Q99471, 154 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	Prefoldin subunit 5
UniProt accession	Q99471
Gene	PFDN5
Organism	Homo sapiens
Length	154 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
ovarian cancer · score 0.25
lung adenocarcinoma · score 0.23
esophageal cancer · score 0.23
gastric adenocarcinoma · score 0.23
neuroblastoma · score 0.15
mean corpuscular volume · score 0.09
triglyceride measurement · score 0.09
bone density · score 0.09
Uveitis · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99471-F1	alphafold	PREDICTED	91.92	—

Amino-acid sequence (154 residues)

MAQSINITEL NLPQLEMLKN QLDQEVEFLS TSIAQLKVVQ TKYVEAKDCL NVLNKSNEGK ELLVPLTSSM YVPGKLHDVE HVLIDVGTGY YVEKTAEDAK DFFKRKIDFL TKQMEKIQPA LQEKHAMKQA VMEMMSQKIQ QLTALGAAQA TAKA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards