D-aspartate oxidase (DDO)

About D-aspartate oxidase

D-aspartate oxidase (DDO) is a protein from Homo sapiens identified by UniProt accession Q99489, 341 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	D-aspartate oxidase
UniProt accession	Q99489
Gene	DDO
Organism	Homo sapiens
Length	341 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.47
platelet component distribution width · score 0.45
platelet count · score 0.45
mean corpuscular volume · score 0.41
mean corpuscular hemoglobin · score 0.36
reticulocyte count · score 0.28
Red cell distribution width · score 0.26
blood metabolite measurement · score 0.26
reticulocyte measurement · score 0.24
serum metabolite measurement · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99489-F1	alphafold	PREDICTED	96.33	—

Amino-acid sequence (341 residues)

MDTARIAVVG AGVVGLSTAV CISKLVPRCS VTIISDKFTP DTTSDVAAGM LIPHTYPDTP IHTQKQWFRE TFNHLFAIAN SAEAGDAGVH LVSGWQIFQS TPTEEVPFWA DVVLGFRKMT EAELKKFPQY VFGQAFTTLK CECPAYLPWL EKRIKGSGGW TLTRRIEDLW ELHPSFDIVV NCSGLGSRQL AGDSKIFPVR GQVLQVQAPW VEHFIRDGSG LTYIYPGTSH VTLGGTRQKG DWNLSPDAEN SREILSRCCA LEPSLHGACN IREKVGLRPY RPGVRLQTEL LARDGQRLPV VHHYGHGSGG ISVHWGTALE AARLVSECVH ALRTPIPKSN L

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards