About Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP2) is a protein
from Homo sapiens identified by UniProt accession
Q99490, 1192 residues long.
MolForge cross-references it against 0 known binders and
131 disease associations.
Target properties
| Protein name | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 |
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| UniProt accession | Q99490 |
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| Gene | AGAP2 |
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| Organism | Homo sapiens |
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| Length | 1192 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (131)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.34
- heel bone mineral density · score 0.17
- nonpapillary renal cell carcinoma · score 0.10
- glioblastoma multiforme · score 0.10
- non-small cell lung carcinoma · score 0.09
- neoplasm · score 0.09
- cancer · score 0.08
- MODY · score 0.08
- cholangiocarcinoma · score 0.08
- platelet count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99490-F1 | alphafold | PREDICTED | 58.60 | — |
Amino-acid sequence (1192 residues)
MSRGAGALQR RTTTYLISLT LVKLESVPPP PPSPSAAAAG AAGARGSETG DPGSPRGAEE PGKKRHERLF HRQDALWIST SSAGTGGAEP PALSPAPASP ARPVSPAPGR RLSLWAVPPG PPLSGGLSPD PKPGGAPTSS RRPLLSSPSW GGPEPEGRAG GGIPGSSSPH PGTGSRRLKV APPPPAPKPC KTVTTSGAKA GGGKGAGSRL SWPESEGKPR VKGSKSSAGT GASVSAAATA AAAGGGGSTA STSGGVGAGA GARGKLSPRK GKSKTLDNSD LHPGPPAGSP PPLTLPPTPS PATAVTAASA QPPGPAPPIT LEPPAPGLKR GREGGRASTR DRKMLKFISG IFTKSTGGPP GSGPLPGPPS LSSGSGSREL LGAELRASPK AVINSQEWTL SRSIPELRLG VLGDARSGKS SLIHRFLTGS YQVLEKTESE QYKKEMLVDG QTHLVLIREE AGAPDAKFSG WADAVIFVFS LEDENSFQAV SRLHGQLSSL RGEGRGGLAL ALVGTQDRIS ASSPRVVGDA RARALCADMK RCSYYETCAT YGLNVDRVFQ EVAQKVVTLR KQQQLLAACK SLPSSPSHSA ASTPVAGQAS NGGHTSDYSS SLPSSPNVGH RELRAEAAAV AGLSTPGSLH RAAKRRTSLF ANRRGSDSEK RSLDSRGETT GSGRAIPIKQ SFLLKRSGNS LNKEWKKKYV TLSSNGFLLY HPSINDYIHS THGKEMDLLR TTVKVPGKRP PRAISAFGPS ASINGLVKDM STVQMGEGLE ATTPMPSPSP SPSSLQPPPD QTSKHLLKPD RNLARALSTD CTPSGDLSPL SREPPPSPMV KKQRRKKLTT PSKTEGSAGQ AEAKRKMWKL KSFGSLRNIY KAEENFEFLI VSSTGQTWHF EAASFEERDA WVQAIESQIL ASLQCCESSK VKLRTDSQSE AVAIQAIRNA KGNSICVDCG APNPTWASLN LGALICIECS GIHRNLGTHL SRVRSLDLDD WPRELTLVLT AIGNDTANRV WESDTRGRAK PSRDSSREER ESWIRAKYEQ LLFLAPLSTS EEPLGRQLWA AVQAQDVATV LLLLAHARHG PLDTSVEDPQ LRSPLHLAAE LAHVVITQLL LWYGADVAAR DAQGRTALFY ARQAGSQLCA DILLQHGCPG EGGSAATTPS AATTPSITAT PSPRRRSSAA SVGRADAPVA LV
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