About Parkinson disease protein 7
Parkinson disease protein 7 (PARK7) is a protein
from Homo sapiens identified by UniProt accession
Q99497, 189 residues long.
MolForge cross-references it against 0 known binders and
424 disease associations.
Target properties
| Protein name | Parkinson disease protein 7 |
|---|
| UniProt accession | Q99497 |
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| Gene | PARK7 |
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| Organism | Homo sapiens |
|---|
| Length | 189 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (424)
Diseases linked to this target (Open Targets).
- Young adult-onset Parkinsonism · score 0.78
- Parkinson disease · score 0.64
- young-onset Parkinson disease · score 0.44
- amyotrophic lateral sclerosis-parkinsonism-dementia complex · score 0.34
- body weight · score 0.33
- ulcerative colitis · score 0.33
- lean body mass · score 0.30
- inflammatory bowel disease · score 0.30
- fat body mass · score 0.28
- Crohn's disease · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99497-F1 | alphafold | PREDICTED | 98.43 | — |
Amino-acid sequence (189 residues)
MASKRALVIL AKGAEEMETV IPVDVMRRAG IKVTVAGLAG KDPVQCSRDV VICPDASLED AKKEGPYDVV VLPGGNLGAQ NLSESAAVKE ILKEQENRKG LIAAICAGPT ALLAHEIGFG SKVTTHPLAK DKMMNGGHYT YSENRVEKDG LILTSRGPGT SFEFALAIVE ALNGKEVAAQ VKAPLVLKD
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