Sphingosine 1-phosphate receptor 3 (S1PR3)

About Sphingosine 1-phosphate receptor 3

Sphingosine 1-phosphate receptor 3 (S1PR3) is a protein from Homo sapiens identified by UniProt accession Q99500, 378 residues long. MolForge cross-references it against 0 known binders and 323 disease associations.

Target properties

Protein name	Sphingosine 1-phosphate receptor 3
UniProt accession	Q99500
Gene	S1PR3
Organism	Homo sapiens
Length	378 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (5)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (323)

Diseases linked to this target (Open Targets).

multiple sclerosis · score 0.60
relapsing-remitting multiple sclerosis · score 0.59
monocyte count · score 0.53
monocyte percentage of leukocytes · score 0.49
leukocyte count · score 0.43
platelet count · score 0.43
HbA1c measurement · score 0.42
granulocyte percentage of myeloid white cells · score 0.42
Red cell distribution width · score 0.42
lymphocyte count · score 0.42

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99500-F1	alphafold	PREDICTED	79.31	—

Amino-acid sequence (378 residues)

MATALPPRLQ PVRGNETLRE HYQYVGKLAG RLKEASEGST LTTVLFLVIC SFIVLENLMV LIAIWKNNKF HNRMYFFIGN LALCDLLAGI AYKVNILMSG KKTFSLSPTV WFLREGSMFV ALGASTCSLL AIAIERHLTM IKMRPYDANK RHRVFLLIGM CWLIAFTLGA LPILGWNCLH NLPDCSTILP LYSKKYIAFC ISIFTAILVT IVILYARIYF LVKSSSRKVA NHNNSERSMA LLRTVVIVVS VFIACWSPLF ILFLIDVACR VQACPILFKA QWFIVLAVLN SAMNPVIYTL ASKEMRRAFF RLVCNCLVRG RGARASPIQP ALDPSRSKSS SSNNSSHSPK VKEDLPHTAP SSCIMDKNAA LQNGIFCN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards