About GAS2-like protein 1
GAS2-like protein 1 (GAS2L1) is a protein
from Homo sapiens identified by UniProt accession
Q99501, 681 residues long.
MolForge cross-references it against 0 known binders and
108 disease associations.
Target properties
| Protein name | GAS2-like protein 1 |
|---|
| UniProt accession | Q99501 |
|---|
| Gene | GAS2L1 |
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| Organism | Homo sapiens |
|---|
| Length | 681 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (108)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.23
- platelet component distribution width · score 0.23
- Immature Reticulocyte Fraction Measurement · score 0.14
- platelet count · score 0.14
- heel bone mineral density · score 0.13
- type 2 diabetes mellitus · score 0.10
- azoospermia · score 0.08
- Red cell distribution width · score 0.07
- hemorrhoid · score 0.07
- Testicular regression syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99501-F1 | alphafold | PREDICTED | 60.00 | — |
Amino-acid sequence (681 residues)
MADPVAGIAG SAAKSVRPFR SSEAYVEAMK EDLAEWLNAL YGLGLPGGGD GFLTGLATGT TLCQHANAVT EAARALAAAR PARGVAFQAH SVVPGSFMAR DNVATFIGWC RVELGVPEVL MFETEDLVLR KNEKSVVLCL LEVARRGARL GLLAPRLVQF EQEIERELRA APPAPNAPAA GEDTTETAPA PGTPARGPRM TPSDLRNLDE LVREILGRCT CPDQFPMIKV SEGKYRVGDS SLLIFVRVLR SHVMVRVGGG WDTLEHYLDK HDPCRCSSTA HRPPQPRVCT FSPQRVSPTT SPRPASPVPG SERRGSRPEM TPVSLRSTKE GPETPPRPRD QLPPHPRSRR YSGDSDSSAS SAQSGPLGTR SDDTGTGPRR ERPSRRLTTG TPASPRRPPA LRSQSRDRLD RGRPRGAPGG RGAQLSVPSP ARRARSQSRE EQAVLLVRRD RDGQHSWVPR GRGSGGSGRS TPQTPRARSP AAPRLSRVSS PSPELGTTPA SIFRTPLQLD PQQEQQLFRR LEEEFLANAR ALEAVASVTP TGPVPDPARA PDPPAPDSAY CSSSSSSSSL SVLGGKCGQP GDSGRTANGL PGPRSQALSS SSDEGSPCPG MGGPLDAPGS PLACTEPSRT WARGRMDTQP DRKPSRIPTP RGPRRPSGPA ELGTWHALHS VTPRAEPDSW M
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