About Flavin-containing monooxygenase 2
Flavin-containing monooxygenase 2 (FMO2) is a protein
from Homo sapiens identified by UniProt accession
Q99518, 535 residues long.
MolForge cross-references it against 0 known binders and
54 disease associations.
Target properties
| Protein name | Flavin-containing monooxygenase 2 |
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| UniProt accession | Q99518 |
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| Gene | FMO2 |
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| Organism | Homo sapiens |
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| Length | 535 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (54)
Diseases linked to this target (Open Targets).
- diffuse plaque measurement · score 0.29
- leukocyte count · score 0.28
- cutaneous melanoma · score 0.18
- serum metabolite measurement · score 0.13
- urinary bladder cancer · score 0.11
- low density lipoprotein cholesterol measurement · score 0.07
- esophageal squamous cell carcinoma · score 0.05
- lung carcinoma · score 0.05
- Barrett's esophagus · score 0.04
- non-small cell lung carcinoma · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99518-F1 | alphafold | PREDICTED | 95.24 | — |
Amino-acid sequence (535 residues)
MAKKVAVIGA GVSGLISLKC CVDEGLEPTC FERTEDIGGV WRFKENVEDG RASIYQSVVT NTSKEMSCFS DFPMPEDFPN FLHNSKLLEY FRIFAKKFDL LKYIQFQTTV LSVRKCPDFS SSGQWKVVTQ SNGKEQSAVF DAVMVCSGHH ILPHIPLKSF PGMERFKGQY FHSRQYKHPD GFEGKRILVI GMGNSGSDIA VELSKNAAQV FISTRHGTWV MSRISEDGYP WDSVFHTRFR SMLRNVLPRT AVKWMIEQQM NRWFNHENYG LEPQNKYIMK EPVLNDDVPS RLLCGAIKVK STVKELTETS AIFEDGTVEE NIDVIIFATG YSFSFPFLED SLVKVENNMV SLYKYIFPAH LDKSTLACIG LIQPLGSIFP TAELQARWVT RVFKGLCSLP SERTMMMDII KRNEKRIDLF GESQSQTLQT NYVDYLDELA LEIGAKPDFC SLLFKDPKLA VRLYFGPCNS YQYRLVGPGQ WEGARNAIFT QKQRILKPLK TRALKDSSNF SVSFLLKILG LLAVVVAFFC QLQWS
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