Sialidase-1 (NEU1)

About Sialidase-1

Sialidase-1 (NEU1) is a protein from Homo sapiens identified by UniProt accession Q99519, 415 residues long. MolForge cross-references it against 0 known binders and 163 disease associations.

Target properties

Protein name	Sialidase-1
UniProt accession	Q99519
Gene	NEU1
Organism	Homo sapiens
Length	415 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (163)

Diseases linked to this target (Open Targets).

sialidosis type 2 · score 0.82
sialidosis type II · score 0.82
sialidosis · score 0.77
sialidosis type I · score 0.69
sialidosis type 1 · score 0.57
neurodegenerative disease · score 0.50
Alzheimer disease · score 0.47
Parkinson disease · score 0.47
lysosomal storage disease · score 0.46
multiple sclerosis · score 0.46

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99519-F1	alphafold	PREDICTED	89.11	—

Amino-acid sequence (415 residues)

MTGERPSTAL PDRRWGPRIL GFWGGCRVWV FAAIFLLLSL AASWSKAEND FGLVQPLVTM EQLLWVSGRQ IGSVDTFRIP LITATPRGTL LAFAEARKMS SSDEGAKFIA LRRSMDQGST WSPTAFIVND GDVPDGLNLG AVVSDVETGV VFLFYSLCAH KAGCQVASTM LVWSKDDGVS WSTPRNLSLD IGTEVFAPGP GSGIQKQREP RKGRLIVCGH GTLERDGVFC LLSDDHGASW RYGSGVSGIP YGQPKQENDF NPDECQPYEL PDGSVVINAR NQNNYHCHCR IVLRSYDACD TLRPRDVTFD PELVDPVVAA GAVVTSSGIV FFSNPAHPEF RVNLTLRWSF SNGTSWRKET VQLWPGPSGY SSLATLEGSM DGEEQAPQLY VLYEKGRNHY TESISVAKIS VYGTL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards