NADPH-dependent quinone oxidoreductase VAT1 (VAT1)

About NADPH-dependent quinone oxidoreductase VAT1

NADPH-dependent quinone oxidoreductase VAT1 (VAT1) is a protein from Homo sapiens identified by UniProt accession Q99536, 393 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.

Target properties

Protein name	NADPH-dependent quinone oxidoreductase VAT1
UniProt accession	Q99536
Gene	VAT1
Organism	Homo sapiens
Length	393 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (26)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.30
leukocyte count · score 0.27
myeloid white cell count · score 0.26
age at menopause · score 0.18
total blood protein measurement · score 0.17
aspartate aminotransferase measurement · score 0.10
age at menarche · score 0.07
menopause · score 0.07
creatinine measurement · score 0.06
eosinophil count · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q99536-F1	alphafold	PREDICTED	90.36	—

Amino-acid sequence (393 residues)

MSDEREVAEA ATGEDASSPP PKTEAASDPQ HPAASEGAAA AAASPPLLRC LVLTGFGGYD KVKLQSRPAA PPAPGPGQLT LRLRACGLNF ADLMARQGLY DRLPPLPVTP GMEGAGVVIA VGEGVSDRKA GDRVMVLNRS GMWQEEVTVP SVQTFLIPEA MTFEEAAALL VNYITAYMVL FDFGNLQPGH SVLVHMAAGG VGMAAVQLCR TVENVTVFGT ASASKHEALK ENGVTHPIDY HTTDYVDEIK KISPKGVDIV MDPLGGSDTA KGYNLLKPMG KVVTYGMANL LTGPKRNLMA LARTWWNQFS VTALQLLQAN RAVCGFHLGY LDGEVELVSG VVARLLALYN QGHIKPHIDS VWPFEKVADA MKQMQEKKNV GKVLLVPGPE KEN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards