About DnaJ homolog subfamily C member 2
DnaJ homolog subfamily C member 2 (DNAJC2) is a protein
from Homo sapiens identified by UniProt accession
Q99543, 621 residues long.
MolForge cross-references it against 0 known binders and
76 disease associations.
Target properties
| Protein name | DnaJ homolog subfamily C member 2 |
|---|
| UniProt accession | Q99543 |
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| Gene | DNAJC2 |
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| Organism | Homo sapiens |
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| Length | 621 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (76)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- lysosomal storage disease · score 0.37
- breast adenocarcinoma · score 0.18
- type 2 diabetes mellitus · score 0.13
- lower face morphology measurement · score 0.11
- metabolite measurement · score 0.10
- neuroblastoma · score 0.07
- bone density · score 0.07
- urate measurement · score 0.07
- blood protein measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q99543-F1 | alphafold | PREDICTED | 84.97 | — |
Amino-acid sequence (621 residues)
MLLLPSAADG RGTAITHALT SASTLCQVEP VGRWFEAFVK RRNRNASASF QELEDKKELS EESEDEELQL EEFPMLKTLD PKDWKNQDHY AVLGLGHVRY KATQRQIKAA HKAMVLKHHP DKRKAAGEPI KEGDNDYFTC ITKAYEMLSD PVKRRAFNSV DPTFDNSVPS KSEAKDNFFE VFTPVFERNS RWSNKKNVPK LGDMNSSFED VDIFYSFWYN FDSWREFSYL DEEEKEKAEC RDERRWIEKQ NRATRAQRKK EEMNRIRTLV DNAYSCDPRI KKFKEEEKAK KEAEKKAKAE AKRKEQEAKE KQRQAELEAA RLAKEKEEEE VRQQALLAKK EKDIQKKAIK KERQKLRNSC KTWNHFSDNE AERVKMMEEV EKLCDRLELA SLQCLNETLT SCTKEVGKAA LEKQIEEINE QIRKEKEEAE ARMRQASKNT EKSTGGGGNG SKNWSEDDLQ LLIKAVNLFP AGTNSRWEVI ANYMNIHSSS GVKRTAKDVI GKAKSLQKLD PHQKDDINKK AFDKFKKEHG VVPQADNATP SERFEGPYTD FTPWTTEEQK LLEQALKTYP VNTPERWEKI AEAVPGRTKK DCMKRYKELV EMVKAKKAAQ EQVLNASRAK K
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